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Database: UniProt
Entry: A0A093F935_TYTAL
LinkDB: A0A093F935_TYTAL
Original site: A0A093F935_TYTAL 
ID   A0A093F935_TYTAL        Unreviewed;       664 AA.
AC   A0A093F935;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   05-JUN-2019, entry version 26.
DE   SubName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000313|EMBL:KFV50689.1};
DE   Flags: Fragment;
GN   ORFNames=N341_07498 {ECO:0000313|EMBL:KFV50689.1};
OS   Tyto alba (Barn owl).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto.
OX   NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV50689.1};
RN   [1] {ECO:0000313|EMBL:KFV50689.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV50689.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KK385266; KFV50689.1; -; Genomic_DNA.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR030739; RapGEF2.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF217; PTHR23113:SF217; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00135}.
FT   DOMAIN      115    215       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   DOMAIN      247    360       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      365    435       PDZ. {ECO:0000259|PROSITE:PS50106}.
FT   DOMAIN      586    664       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION       18     79       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A093F935}.
FT   COILED      208    228       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     18     45       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A093F935}.
FT   COMPBIAS     61     76       Acidic. {ECO:0000256|MobiDB-lite:
FT                                A0A093F935}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFV50689.1}.
FT   NON_TER     664    664       {ECO:0000313|EMBL:KFV50689.1}.
SQ   SEQUENCE   664 AA;  74412 MW;  F615763482C96037 CRC64;
     LPADFTKLHL TDSLHPQVTH VSSSHSGCSI TSDSGSSSLS DIYQATESEA GDMDLSGLPE
     TAVDSEDDDD EEDIERASDP LMSRDIVRDC LEKDPIDRTD DDIEQLLEFM HQLPAFANMT
     MSVRRELCAV MVFAVVERAG TIVLNDGEEL DSWSVILNGS VEVTYPDGRT EILCMGNSFG
     VSPTMEKEYM KGVMRTKVDD CQFVCIAQQD YCRILNQVEK NMQKVEEEGE IVMVKEHREL
     DRTGTRKGHI VIKGTAERLT MHLVEEHSVV DPTFIEDFLL TYRTFLSSPM EVGKKLLEWF
     NDPSLRDKVT RVVLLWVNNH FNDFEGDPAM TRFLEEFENN LEREKMGGHL RLLNIACAAK
     AKRRLITLTK PSREAPLPFI LLGGSEKGFG IFVDSVDFGS KATEAGLKRG DQILEVNGQN
     FENIQLSKAM EILRNNTHLS ITVKTNLFVF KELLTRLSEE KRNGAPHLPK IGDIKKASRY
     SIPDLAVDVE QVIGLEKVNK KSKANTVGGR NKLKKILDKT RISILPQKPY NDIGIGQSQD
     DSIVGLRQTK HIPPALPVSG TLSSSNPDLL QSHHRILDFN TTPDLPDQVL RVFKADQQSR
     YIMISKDTTA KEVVIQAIRE FALTATPDAY SLCEVSVTPE GVIKQRRLPD QLSKLADRIQ
     LSGR
//
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