ID A0A093FA01_TYTAL Unreviewed; 572 AA.
AC A0A093FA01;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG1 {ECO:0000256|ARBA:ARBA00040478};
DE EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
DE AltName: Full=Acyl-CoA synthetase bubblegum family member 1 {ECO:0000256|ARBA:ARBA00043191};
DE Flags: Fragment;
GN ORFNames=N341_09998 {ECO:0000313|EMBL:KFV51039.1};
OS Tyto alba (Barn owl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto.
OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV51039.1, ECO:0000313|Proteomes:UP000054190};
RN [1] {ECO:0000313|EMBL:KFV51039.1, ECO:0000313|Proteomes:UP000054190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV51039.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP
CC + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526,
CC ChEBI:CHEBI:72745, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00036716};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-
CC CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379,
CC ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00036355};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00036813};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541}. Endoplasmic
CC reticulum {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Microsome
CC {ECO:0000256|ARBA:ARBA00004144}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC Bubblegum subfamily. {ECO:0000256|ARBA:ARBA00038034}.
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DR EMBL; KK385991; KFV51039.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093FA01; -.
DR Proteomes; UP000054190; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05933; ACSBG_like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272:SF93; ACYL-COA SYNTHETASE BUBBLEGUM FAMILY MEMBER 1; 1.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022848};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KFV51039.1};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Reference proteome {ECO:0000313|Proteomes:UP000054190}.
FT DOMAIN 2..381
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV51039.1"
FT NON_TER 572
FT /evidence="ECO:0000313|EMBL:KFV51039.1"
SQ SEQUENCE 572 AA; 64022 MW; D7E5D85EABC17511 CRC64;
KLGLERFHSV AILGFNSPEW FISAVGTVFA GGILTGIYTT NSPEACHYIA HDSKTNIMVV
ENRKQLDKIM QIWNRLPHLK AVVLYKDSIL ERHPNLYTME EFLELGDDVS DTTLDDIINS
QKPNQCCVLI YTSGTTGKPK GAMLSHDNIT WTSAHCSRAG DMQPAEVQQE SIVSYLPLSH
IAAQIYDLWT GIKWGEQVYF AEPDALKGSL INTLKEVQPT SHMGVPRVWE KIMEKLKDAS
AQSGFMKKKM LSWAMSLSLE RNLNCSSSSD LKQFWTRLAD YLVLSKIRNA LGFSSCQKHF
CGAAPLNTET LYFFLGLNIT LYEAYGMSET TGPHCLSGPY IYRQHSCGKP VPGCRVKLVD
EDTEGSGEIC FWGRTVFMGY LNMEDKTKEA FDEDGWLHSG DLGKLDKDGF VYVTGRIKDL
IITAGGENVP PIPIEDAIKK ELPIVSNAMV IGDKKKFLAM LLTLKSVLDP DTSDPTDVLT
EQARDFCQKT GSKATKVSEI VATRDQAIYQ AIQEGINKVN MNATNRVHCI QKWIVLPRDF
SISGGELGPT MKLKRLTVLE KYRNEIDSFY EE
//
