ID A0A093FDZ0_TYTAL Unreviewed; 499 AA.
AC A0A093FDZ0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit {ECO:0000256|ARBA:ARBA00031109};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
DE Flags: Fragment;
GN ORFNames=N341_06365 {ECO:0000313|EMBL:KFV54775.1};
OS Tyto alba (Barn owl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto.
OX NCBI_TaxID=56313 {ECO:0000313|EMBL:KFV54775.1, ECO:0000313|Proteomes:UP000054190};
RN [1] {ECO:0000313|EMBL:KFV54775.1, ECO:0000313|Proteomes:UP000054190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N341 {ECO:0000313|EMBL:KFV54775.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
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DR EMBL; KK391114; KFV54775.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093FDZ0; -.
DR UniPathway; UPA00363; UER00861.
DR Proteomes; UP000054190; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR Pfam; PF01039; Carboxyl_trans; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054190}.
FT DOMAIN 6..263
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 252..491
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV54775.1"
FT NON_TER 499
FT /evidence="ECO:0000313|EMBL:KFV54775.1"
SQ SEQUENCE 499 AA; 54224 MW; B3CB825240582028 CRC64;
ENYERMKALV TELQEQAEKI RLGGGEKARK LHTSRGKLLP RERIDRLIDP GSPFLEFSQF
AGYQLYGNEE VPAGGIITGI GRVSGVECLI VANDATVKGG TYYPITVKKH LRAQEIAMQN
HLPCLYLVDS GGANLPRQAE VFPDRDHFGR IFYNQAVMSS QGIPQIAVVM GSCTAGGAYV
PAMADESIIV GKQGTIFLGG PPLVKAATGE EVSAEDLGGA DLHCRKSGVT DHYALDDNHA
LHLARKAVRS LNLQKKVDAF HYIFLFFLKV IARIVDGSKF DEFKALYGDT LITGFARIFG
YPVGIIGNNG VLFSESAKKG THFIQLCCQR NIPIVFLQNI TGFMVGREYE AGGIAKDGAK
MVTAVACANV PKITVIIGGS YGAGNYGMCG RAYSPRFLYV WPNARISVMG GEQAATVLAT
IAKDRKAREG KQLSEADEAA LKEPIIRRFE EEGNPYYSSA RLWDDGIIDP ADTRLVLGLS
LSAALNAPTK KTEFGVFRM
//
