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Database: UniProt
Entry: A0A093FI10_GAVST
LinkDB: A0A093FI10_GAVST
Original site: A0A093FI10_GAVST 
ID   A0A093FI10_GAVST        Unreviewed;      1338 AA.
AC   A0A093FI10;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   12-SEP-2018, entry version 22.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE   Flags: Fragment;
GN   ORFNames=N328_00884 {ECO:0000313|EMBL:KFV53919.1};
OS   Gavia stellata (Red-throated diver) (Red-throated loon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia.
OX   NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV53919.1, ECO:0000313|Proteomes:UP000054313};
RN   [1] {ECO:0000313|EMBL:KFV53919.1, ECO:0000313|Proteomes:UP000054313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV53919.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; KK627432; KFV53919.1; -; Genomic_DNA.
DR   Proteomes; UP000054313; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 3.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054313};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054313};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    119    139       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    145    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    244    266       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    322    344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    788    807       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    827    848       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    860    878       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    921    943       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1033   1058       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1114   1132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1144   1167       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1179   1203       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1224   1253       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1322   1337       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      117    353       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      789   1064       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1110   1338       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED        9     29       {ECO:0000256|SAM:Coils}.
FT   COILED      353    380       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFV53919.1}.
FT   NON_TER    1338   1338       {ECO:0000313|EMBL:KFV53919.1}.
SQ   SEQUENCE   1338 AA;  153662 MW;  60797B0D9E2C925B CRC64;
     LRSEFAKERE RVENRRAFLK LRRQQQIERE LNGYLEWIFK AEEVMLAEED KNAEEKSPLD
     VLKRAAIKKS KNDLIHAEEG SPFARASLKS GKNESSSYFR RKEKMFRFFI RRMVKAQSFY
     WIVLCVVALN TLCVAMVHYD QPEKLTTALY FAEFVFLGLF LTEMSLKMYG LGPRNYFHSS
     FNCFDFGVIV GSIFEVIWAA VKPGTSFGIS VLRALRLLRI FKVTKYWNSL RNLVVSLLNS
     MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFQDETPTTN FDTFPAAILT VFQILTGEDW
     NAVMYHGIES QGGVRSGMFS SIYFIVLTLF GNYTLLNVFL AIAVDNLANA QELTKDEEEM
     EEATNQKLAL QKAKEVAEVS PMSAANISIA AKQQNSSKSK SVWEQRTSQI RMHNFRASCE
     ALYNELDPEE RVRYATTLHI RPDMKTHLDR PLVVEPRGEG RNNVSKLSPV DVQEVEQTKV
     SSTDGAEAPR KHHRHRDKDK LGEQEKGDVT KDENGESGAN NKEERHRQHR SRSKEVEGGS
     KEGKSDRNRS QEGGKRHHRR GSVEEGAEKE HRRHRTHRHS AERQGKEGNG TINGARSERR
     SRHRGGSRSG NREGEPGSKG ENGEEPHRRH RFRNRALSTY DSVEKENGEK EGEAGEKEHR
     NHQPKENQCE IEASGSVSVP VHTLPSTYLQ KVPEQPEDAD NQKNVTRMIQ PPLDKTTTVN
     IPVTITAPPG ETTVIPMNNV EFESKTEEKK DVDDLTKNGP KPILPYSSMF ILSPTNPIRR
     LFHYIVNLRY FEMVILIVIA LSSIALAAED PVQAESPRND ALKYLDYIFT GVFTFEMVIK
     MIDLGLLLHP GSYFRDLWNI LDFIVVSGAL VAFAFSGTKG KDINTIKSLR VLRVLRPLKT
     IKRLPKLKAV FDCVVNSLKN VLNILIVYML FMFIFAVIAV QLFKGRFFYC TDESKELEKD
     CRGQYLDYEK NEVEAQPREW KKYEFHYDNV LWALLTLFTV STGEGWPTVL KHSVDATYEE
     QGPSPGYRME MSIFYVVYFV VFPFFFVNIF VALIIITFQE QGDKVMSECS LEKNERACID
     FAISAKPLTR YMPQNKQSFQ YKMWKFVVSP PFEYFIMVMI ALNTIVLMMK FYDAPEAYEE
     MLKCLNIVFT SMFSMECVLK IIAFGVLNYF RDAWNVFDFV TVLGSITDIL VTEIADNFIN
     LSFLRLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC LLIAMLFFIY AIIGMQVFGN
     IALDDETSIN RHNNFRTFLQ ALMLLFRSAT GEAWHEIMLS CLSNRACDPL SGLTKNECGS
     DFAYFYFVSF IFLCSFLV
//
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