ID A0A093FXE0_GAVST Unreviewed; 260 AA.
AC A0A093FXE0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Pro-thyrotropin-releasing hormone {ECO:0000256|PIRNR:PIRNR001795};
GN ORFNames=N328_07262 {ECO:0000313|EMBL:KFV59024.1};
OS Gavia stellata (Red-throated diver) (Colymbus stellatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia.
OX NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV59024.1, ECO:0000313|Proteomes:UP000054313};
RN [1] {ECO:0000313|EMBL:KFV59024.1, ECO:0000313|Proteomes:UP000054313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV59024.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems.
CC {ECO:0000256|PIRNR:PIRNR001795}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000256|ARBA:ARBA00010437,
CC ECO:0000256|PIRNR:PIRNR001795}.
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DR EMBL; KK637053; KFV59024.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093FXE0; -.
DR Proteomes; UP000054313; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR InterPro; IPR008857; TRH.
DR PANTHER; PTHR17530; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR PANTHER; PTHR17530:SF2; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|PIRNR:PIRNR001795};
KW Reference proteome {ECO:0000313|Proteomes:UP000054313};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001795};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR001795}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT CHAIN 20..260
FT /note="Pro-thyrotropin-releasing hormone"
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT /id="PRO_5010009628"
FT REGION 55..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 260 AA; 30363 MW; DAA9DCBDD2308E91 CRC64;
MPSMHLPLLL LCLTLCGVCL NGRQPLPEGS ENMGRSPLDD ILQRSESRIL QSVLKKAEKE
EDMNKESNTP LPEWLSKRRH PGKRYLSDLK KRQHPGKRDV EEDTSYGDIQ KRQHPGKREI
EDDLDGYLEL KKRQHPGRRS LSDQYVDIPS AQLTYLNELS KRQHPGRRYL MYTRQYPSKR
GWNDEVDLND QYGEKRQHPG KRHWNSHSPD DAGPCNFQES FTCNKGSLLL DLVENVSKDR
VEEKRQHPGK RSAWENETDK
//
