ID A0A093FY10_DRYPU Unreviewed; 882 AA.
AC A0A093FY10;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Sodium/calcium exchanger 1 {ECO:0000313|EMBL:KFV61718.1};
DE Flags: Fragment;
GN ORFNames=N307_07869 {ECO:0000313|EMBL:KFV61718.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV61718.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV61718.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV61718.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL214756; KFV61718.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093FY10; -.
DR STRING; 118200.A0A093FY10; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF6; SODIUM/CALCIUM EXCHANGER 1; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 257..320
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV61718.1"
FT NON_TER 882
FT /evidence="ECO:0000313|EMBL:KFV61718.1"
SQ SEQUENCE 882 AA; 97685 MW; CD7CE08AE3781C9C CRC64;
CTGSYICKKG VILPIWEPQD PSFGDKIARA TVYFVAMVYM FLGVSIIADR FMSSIEVITS
QEREITIKKP NGETSKTTVR IWNETVSNLT LMALGSSAPE ILLSVIEVCG HGFTAGDLGP
STIVGSAAFN MFVIIAICVY VVPDGEIRKI KHLRVFFVTA AWSIFAYTWL YIILSVSSPG
VVEVWEGLLT FFFFPICVVF AWIADRRLLF YKYVYKKYRA GKQRGMIIEH EGDRPSSKAD
IEMDGKVANS HVENFLDGTL VLEVDEKDQD DEEARREMAR ILKELKQKHP EKEVEQLIEL
ANYQVLSQQQ KSRAFYRIQA TRLMTGAGNI LKRHAADQAR KAVSMQEVNG EAAENDPVSK
LCFEQATYQC LDPGALTVVR RGGDLTKTVC VDFRTEDGTA NAGSDYEFTE GTVVFKPGET
QKEIRVGIID DDIFEEDENF LVHLSNVRPG AEASDEGVPE AGPGVAGLLA CLGSPSTATV
TIFDDDHAGI FTFEEPVTHV SESVGTMEVK VLRTSGARGN VIVPYKTVEG SAKGGGEDFE
DTCGELEFQN DEIVKFIPLR VLDREEYEKE CSFFLVLGDP VWLRRGVKEE SEEKQPLTSK
EEEERRIAEM GRPILGEHTK LEVIIEESYE FKNTVDKLIK KTNLALVVGT NSWREQFIEA
ITVSAGEDDD DDECGEEKLP SCFDYVMHFL TVFWKVLFAF VPPTDYWNGW ACFVVSILMI
GLLTAFIGDL ASHFGCTIGL KDSVTAVVFV ALGTSVPDTF ASKVAATQDQ YADASIGNVT
GSNAVNVFLG IGVAWSIAAI YHAAHGQAFQ VSPGTLAFSV TLFTIFAFIS VGVLLYRRRP
EIGGELGGPR TSKLLTSSLF ILLWLLYIFF SSLEAYCHIK GF
//