ID   A0A093FYL8_DRYPU        Unreviewed;       897 AA.
AC   A0A093FYL8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   RecName: Full=GPI inositol-deacylase {ECO:0000256|RuleBase:RU365011};
DE            EC=3.1.-.- {ECO:0000256|RuleBase:RU365011};
DE   Flags: Fragment;
GN   ORFNames=N307_08537 {ECO:0000313|EMBL:KFV63010.1};
OS   Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX   NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV63010.1, ECO:0000313|Proteomes:UP000053875};
RN   [1] {ECO:0000313|EMBL:KFV63010.1, ECO:0000313|Proteomes:UP000053875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV63010.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in inositol deacylation of GPI-anchored proteins.
CC       GPI inositol deacylation may important for efficient transport of GPI-
CC       anchored proteins from the endoplasmic reticulum to the Golgi.
CC       {ECO:0000256|RuleBase:RU365011}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the GPI inositol-deacylase family.
CC       {ECO:0000256|ARBA:ARBA00006931, ECO:0000256|RuleBase:RU365011}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU365011}.
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DR   EMBL; KL215029; KFV63010.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093FYL8; -.
DR   STRING; 118200.A0A093FYL8; -.
DR   Proteomes; UP000053875; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR012908; PGAP1-like.
DR   InterPro; IPR039529; PGAP1/BST1.
DR   PANTHER; PTHR15495:SF7; GPI INOSITOL-DEACYLASE; 1.
DR   PANTHER; PTHR15495; NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED; 1.
DR   Pfam; PF07819; PGAP1; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU365011};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365011};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365011};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU365011};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365011};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365011};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365011}.
FT   TRANSMEM        578..600
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365011"
FT   TRANSMEM        621..639
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365011"
FT   TRANSMEM        659..681
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365011"
FT   TRANSMEM        713..737
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365011"
FT   TRANSMEM        794..813
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365011"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFV63010.1"
FT   NON_TER         897
FT                   /evidence="ECO:0000313|EMBL:KFV63010.1"
SQ   SEQUENCE   897 AA;  101590 MW;  CA6976F88CDE633F CRC64;
     LGVRDVLFFY EENRCSMTYM YEYPEYLKIK LPKKIARRYP AYELYLYGEG SYAEENKNLL
     LTGIPVLFLP GNAGSYKQVR SLGSIALRKA EDVDFKYHFD FFSVNFNEEL VALYGGSLQR
     QTKFVHECIK VILKLYKGRE FAPTSVAIVG HSMGGLVARA LLTLKNFKPE LINLLITQAT
     PHTAPVMALD KYLTDFYTAV NNHWILKAQD LRNLTTLSVA GGFRDYQVRS GLAFLPRLNQ
     HDSALSVVSS AVPRAWASTD HLSIVWCKEL ILATVRAFFD LIDENTRQIT EDPKKRMSVL
     NHHFVRHPAK IFEENPEAFT ELTGTFTWIT VRGSKWTYSV YNDSDGKYFT YPLASHRKSY
     SHIYCENSML DTSSWIYGCL KSNSSMCLEA TDLSWRAELL PTTKIVLLKL QDYPSLSHIV
     IQVPPAAGNK YTLTCEFFRE DSRAVQLPVT HLLSFGLSSS KILLNSSGLL YNVQLQHFHQ
     IYQAFKIYIE SHCQSHKERK PSVYRLHIPW SHEDSITVAK VPSLTEISAK LHTAQPQNDS
     SVPELNIYSS SDCQYEVVLK TSLLQVLGQI IRFHAGALPV YVVCNILLAY GGQLSTLMSI
     GQCSDFSHEL VRTAKPYKVE PLISIVVFLL GFNWFREIWE SLSLPEVDAA ILSSQDAWFP
     LVSLILFLFG TGIAYWSGVF FSTSLRLFSS LWLTLIRPPV LGKDDKLITP RRLCGVLSLC
     LISWTTCGAF AVFLIYLQYL FKDSDCSKET SQNLNMPTVK PQSLITSTSK ATQPLSNSTT
     TAEVLNSLKM HVTILNLFTW TVLLYSPSLI YWLKNLRYNV RLDPDPCRST ALILICILEI
     LMNSSTSKVK SSKLLKIAAK VPLPLSVAML AFGRLHLFKV PHFVTFSLLL HVLCCIV
//