ID A0A093G0H6_GAVST Unreviewed; 1025 AA.
AC A0A093G0H6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE Flags: Fragment;
GN ORFNames=N328_11342 {ECO:0000313|EMBL:KFV60151.1};
OS Gavia stellata (Red-throated diver) (Colymbus stellatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia.
OX NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV60151.1, ECO:0000313|Proteomes:UP000054313};
RN [1] {ECO:0000313|EMBL:KFV60151.1, ECO:0000313|Proteomes:UP000054313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV60151.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; KK639128; KFV60151.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093G0H6; -.
DR Proteomes; UP000054313; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR CDD; cd14043; PK_GC-2D; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF477; GUANYLATE CYCLASE D; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054313};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 498..756
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 830..960
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 767..794
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV60151.1"
FT NON_TER 1025
FT /evidence="ECO:0000313|EMBL:KFV60151.1"
SQ SEQUENCE 1025 AA; 114795 MW; 413CAE762BBF3E9B CRC64;
FKIGLLGPWN CDPFFSKAFP HVAARIAVGR ISKDPSLDLG HRLDYVVLQE ECETSRALVR
FIDFGKLSSA FIGPLNPGFC EVATLLGENW NKAIFSWMCI NYKLDSTIHH PTFARTLPSP
TRVLFTIMKY FNWARVGIIA SNEDIWMDTA NKLASALRNQ GLPVGIVTSM RKGEKGIEDT
WNEIKEVDGI RIILLCMHSV LVGGEEQATL LTKALEMGLA DGRYVFVPYD TLLYSLPYQN
NSFNIFDNDS KLQEAYDAVL TVTLESGERT FYDAFREAKE SGEITSDLEA TQVSPLFGTI
YDAIYFMAMA LDSARRKGVR ISGANIAEHT KNFSFPGFSH WIETDNCGKG LSNYVILDTD
GHGNQLFPTH LLDMSSDSVK SLARAIHFPS GAPPKPDSSC WFDPDVLCTG GIEPTVMVLG
VMLIFALVLC AVGLASLIRH SILNSQLFRG PNKIILTLDD LVFINPELHK KRLTLDSLTD
ANSVAADGRS LKSVTRSFSL KSTAATHETS NVALYEGDWV WLKKFETGAV HNLRQSSTSI
LRKMKELRHE NVNLFLGFFS DCGIFAIVTE YCSRGSLEDL LKNEDMKLDW MFKSSLVMDL
IKGIRYLHHR DFAHGRLKSR NCVVDGRFVL KITDYGYNEL LEAQKCPYIH PPPEELLWTA
PELLRDPDMC RKGTFKGDIY SFAIILQEVV VRGPPYCMSE LSAEEIIKKV KKPPPLCRPN
IAPELAPLEC IQVMKQCWGE APERRPTFEE VFHKFKTINK GKKTNIIDSM LRMLEQYSSN
LEDLIRERTE ELEIEKQKTE KLLSQMLPPS VAEALKTGGT VEPEYFDQVT IYFSDIVGFT
TISALSEPIE VVDLLNDLYT LFDAVLGNHD VYKVETIGDA YMVASGLPKR NGNKHAAEIA
NMSLDILSSV GTFKMRHMPD IPLRIRIGLH TGPCVAGVVG LTMPRYCLFG DTVNTASRME
STGLPYRIHV SQSTVDTLRS LNEGYEIVPR GKTELKGKGV EDTYWLVGKK GFLKPLPKPP
EIKPG
//
