ID A0A093G363_DRYPU Unreviewed; 1318 AA.
AC A0A093G363;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=DNA repair protein RAD50 {ECO:0000313|EMBL:KFV64625.1};
GN ORFNames=N307_02794 {ECO:0000313|EMBL:KFV64625.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV64625.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV64625.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV64625.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}.
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
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DR EMBL; KL215442; KFV64625.1; -; Genomic_DNA.
DR STRING; 118200.A0A093G363; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR004584; Rad50_eukaryotes.
DR InterPro; IPR013134; Zn_hook_RAD50.
DR NCBIfam; TIGR00606; rad50; 1.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13476; AAA_23; 1.
DR Pfam; PF04423; Rad50_zn_hook; 1.
DR Pfam; PF13558; SbcC_Walker_B; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51131; ZN_HOOK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00471}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00471}.
FT DOMAIN 641..740
FT /note="Zinc-hook"
FT /evidence="ECO:0000259|PROSITE:PS51131"
FT COILED 203..349
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 401..435
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 467..527
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 586..661
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 718..828
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 852..1076
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 687
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
FT BINDING 690
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
SQ SEQUENCE 1318 AA; 153467 MW; B408C92C90641690 CRC64;
MSRIEKMSIL GVRSFGVEDK DKQIITFFNP LTILVGPNGA GKTTIIECLK YISTGDFPPG
TKGNSFVHDP KVANETDVRA QIRLQFRDVN GEPLAVQRSM ICTQKGKKTE FKTLESVITR
TRHGEKVSLS SKCAEIDREM ISALGVSKAV LNNVIFCHQE ESNWPLSEGK ALKQKFDEIF
SATRYIKALE TLRQVRMKQS SKVKECQTEL KYLKQNKEKA QEIQDQLSNR EAQLMASKEN
VKSIESQLEP LKSSLASVEQ NLMKVMKLDN EVKALESRRR QMEKDNQDLQ QKMEKVFQGT
DEQLRDRYEN HQKTVKEKEK RLSDCKHELD RATKECQRFN SEKSELLVER GRLQLQADRH
QEHVSTRDSL VQSLAAQLGI DGFERAPFND RHIASFHTLV RERQDREAEA AERAMREYAR
KEAVKQKQIE EIRDKKTGLE RTIDLKSDIQ NKKQVELKNV KHELQQLEGF SDRILELDQE
IAKTEHELEK AERSSNIKTL EQEVQTLQNE KITLDKALRK LDQEMDQLNL HTMTITQMEM
LKKDKVIFLS SSYKEEQIRK VKSRHSEELT SLMGYFPNKN QLEDWLHAQN RKINQTRDNL
AALNKRLASV ESDKTHTSNE LKKKEEQLYD HETRLSDVCG SQDFDSDLKK LQDDIEKSSK
QRAVLAGATA VFSQFITQLT EENQPCCPVC QRVFQTEVEL QDVISDLQSK LRLAPDKLKS
TESELKRKEK KRDEMMSLKP LRQTVAELQD RDIPNLRNKV QNANRDLTSL KAEIEEQETA
LQTAMTEEES GKACLQDVTL MERYQTDIKD LERKIAQQEA KLLGVDLSRT VLQVSQEKQE
NKHLWDTVTG KIELKQKLKQ DQQNQIQQLK SAVNDLKAEK LQISSGMQRR RQLEEQTVEL
TTEVQSLCRE IKEAKEQVFP LNATLDELQQ EKEDLVSKRT ACNKEAQEKM NGIKEKVKDI
NKYVKEIDSY IQQRKDDYKK QKESELEEVN SQLAACEKQK EKISKEMETI RQDIDTKKIQ
ERWLQDNLTL RERNKELKGV EDNIKHLMKE MGEMKVPQLR NEQNRLEERI ESLKRSHHLA
LGRQHGFEEE IIRFKKELRE PQFRDAEETY REMMIVMRTT ELANKDLDLY YKALDKAIMT
FHSMKMEEIN KIIRDLWRST YRGQDIEYVE IRSDADENVS ASDKRRSYNY RVVMVKGDTA
LDMRGRCSAG QKVLASLIIR LALAETFCLN CGILALDEPT TNLDRENIES LAHALVEIIK
SRSQQRNFQL LVITHDEDFV ELLGRSEYVE KFYRIKKNLD QCSEIMKCSV SSLGSYVH
//
