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Database: UniProt
Entry: A0A093G761_DRYPU
LinkDB: A0A093G761_DRYPU
Original site: A0A093G761_DRYPU 
ID   A0A093G761_DRYPU        Unreviewed;       900 AA.
AC   A0A093G761;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   03-MAY-2023, entry version 32.
DE   RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE            EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
DE   Flags: Fragment;
GN   ORFNames=N307_01269 {ECO:0000313|EMBL:KFV66050.1};
OS   Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX   NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV66050.1, ECO:0000313|Proteomes:UP000053875};
RN   [1] {ECO:0000313|EMBL:KFV66050.1, ECO:0000313|Proteomes:UP000053875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV66050.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000435};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC         Evidence={ECO:0000256|ARBA:ARBA00000435};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000417};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC         Evidence={ECO:0000256|ARBA:ARBA00000417};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004888}.
CC   -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC       {ECO:0000256|ARBA:ARBA00005028}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225}.
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DR   EMBL; KL215662; KFV66050.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093G761; -.
DR   STRING; 118200.A0A093G761; -.
DR   UniPathway; UPA00109; UER00180.
DR   UniPathway; UPA00242; -.
DR   Proteomes; UP000053875; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 3.40.367.20; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF28; HEXOKINASE HKDC1; 1.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFV66050.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          2..204
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          211..444
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
FT   DOMAIN          455..651
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          657..891
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFV66050.1"
FT   NON_TER         900
FT                   /evidence="ECO:0000313|EMBL:KFV66050.1"
SQ   SEQUENCE   900 AA;  99958 MW;  1A56ACF1D50688FE CRC64;
     QVDRYLYHMR LSDDALLDVM ARFQAEMVKG LGRDTNPTAA VKMLPTFVRS LPDGSEKGEF
     LAVDLGGSQF RAHQVKVFDD GKQSSQLESK FYPTPKEVIE GSGAELFDYV VDCLADFMET
     KNLKHKKLPL GFTFSFPCKQ TKLEEGFLLG WTKHFKVRGV QDTDVVNSLR KALKKHKASF
     VPAEDLEVLA LVNDTVGTMM TCGYDDPRCE VGLIIGTGTN ACYMEDMRHI DLVEGDEGRM
     CINTEWGAFG DDGALDDLRT EFDQELDLGS LNPGKQLFEK MISSLHLGEL VRLILLKMTK
     EGLLFNGKVS TALLTKGKIE MKHICAMEKY KEGLGNTKEI LTELNLFPTE EDCIAVQHVC
     TIVSFRSANL CAAALAAILT RLRENKKLLR MRTTVGIDGG LYKTHPQYAK RLHKVVRRLV
     PNCDVRFILS ESGSGKGAAM VTAVGYRLAA QRKRIDAALA PFLLSLDTLR EVKNKMRTEL
     EYGLKRETQA SASVKMLPTY VCGTPDGTEK GKFLALDLGG TNFRVLLVKI RSGRRSVRMY
     NKIFAIPLEI MQGTGEELFD HIVQCIADFL EYMGLKGARL PLGFTFSFPC RQASIDKGTL
     VGWTKGFKAT DCEGEDVVDM LREAIKRRNE FDLDIVAVVN DTVGTMMTCG YEDPNCEIGL
     IAGTGSNVCY MEDMKNIEIV EGNEGKMCIN TEWGGFGDNG CIDNIRTKYD KEVDEGSLNP
     GKQRYEKMTS GMYLGEIVRQ ILIDLTKQGL LFRGQISESL RKRGIFETKF LSQIESDRLA
     LLQVRLILQQ LGLDSTCEDS IIVKEVCGAV SRRAAQLCGA GLAAIVEKKR ENQGVERLQI
     TVGVDGTLYK LHPHFSRVLQ ETVKQLAPQC DVTFMLSEDG SGKGAALITA VAKRLHNVGQ
//
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