ID A0A093G761_DRYPU Unreviewed; 900 AA.
AC A0A093G761;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 32.
DE RecName: Full=hexokinase {ECO:0000256|ARBA:ARBA00012324};
DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324};
DE Flags: Fragment;
GN ORFNames=N307_01269 {ECO:0000313|EMBL:KFV66050.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV66050.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV66050.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV66050.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
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DR EMBL; KL215662; KFV66050.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093G761; -.
DR STRING; 118200.A0A093G761; -.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.367.20; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF28; HEXOKINASE HKDC1; 1.
DR Pfam; PF00349; Hexokinase_1; 2.
DR Pfam; PF03727; Hexokinase_2; 2.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 4.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFV66050.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..204
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 211..444
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT DOMAIN 455..651
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 657..891
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV66050.1"
FT NON_TER 900
FT /evidence="ECO:0000313|EMBL:KFV66050.1"
SQ SEQUENCE 900 AA; 99958 MW; 1A56ACF1D50688FE CRC64;
QVDRYLYHMR LSDDALLDVM ARFQAEMVKG LGRDTNPTAA VKMLPTFVRS LPDGSEKGEF
LAVDLGGSQF RAHQVKVFDD GKQSSQLESK FYPTPKEVIE GSGAELFDYV VDCLADFMET
KNLKHKKLPL GFTFSFPCKQ TKLEEGFLLG WTKHFKVRGV QDTDVVNSLR KALKKHKASF
VPAEDLEVLA LVNDTVGTMM TCGYDDPRCE VGLIIGTGTN ACYMEDMRHI DLVEGDEGRM
CINTEWGAFG DDGALDDLRT EFDQELDLGS LNPGKQLFEK MISSLHLGEL VRLILLKMTK
EGLLFNGKVS TALLTKGKIE MKHICAMEKY KEGLGNTKEI LTELNLFPTE EDCIAVQHVC
TIVSFRSANL CAAALAAILT RLRENKKLLR MRTTVGIDGG LYKTHPQYAK RLHKVVRRLV
PNCDVRFILS ESGSGKGAAM VTAVGYRLAA QRKRIDAALA PFLLSLDTLR EVKNKMRTEL
EYGLKRETQA SASVKMLPTY VCGTPDGTEK GKFLALDLGG TNFRVLLVKI RSGRRSVRMY
NKIFAIPLEI MQGTGEELFD HIVQCIADFL EYMGLKGARL PLGFTFSFPC RQASIDKGTL
VGWTKGFKAT DCEGEDVVDM LREAIKRRNE FDLDIVAVVN DTVGTMMTCG YEDPNCEIGL
IAGTGSNVCY MEDMKNIEIV EGNEGKMCIN TEWGGFGDNG CIDNIRTKYD KEVDEGSLNP
GKQRYEKMTS GMYLGEIVRQ ILIDLTKQGL LFRGQISESL RKRGIFETKF LSQIESDRLA
LLQVRLILQQ LGLDSTCEDS IIVKEVCGAV SRRAAQLCGA GLAAIVEKKR ENQGVERLQI
TVGVDGTLYK LHPHFSRVLQ ETVKQLAPQC DVTFMLSEDG SGKGAALITA VAKRLHNVGQ
//