ID A0A093GBE5_DRYPU Unreviewed; 844 AA.
AC A0A093GBE5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=N307_13313 {ECO:0000313|EMBL:KFV64202.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV64202.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV64202.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV64202.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL215321; KFV64202.1; -; Genomic_DNA.
DR RefSeq; XP_009894675.1; XM_009896373.1.
DR AlphaFoldDB; A0A093GBE5; -.
DR STRING; 118200.A0A093GBE5; -.
DR GeneID; 104296552; -.
DR KEGG; dpub:104296552; -.
DR CTD; 50617; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF26; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 398..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 447..466
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 545..566
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 572..596
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 641..662
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 776..800
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 674..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 51..120
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 688..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 844 AA; 96670 MW; 2868B527FD5191E9 CRC64;
MASVFRSEEM SLMQLFLQVE AAYCCVAELG ELGLVQFRDL NANVNSFQRK FVNEVRRCES
LERILRFLEN EMEDSAEIVK LEKYPETPLP REMIDMETVL EKLEAELLEA NQNQQTLKQN
FLELTELKLL LKKTQDFFEA ETNLPDDFFS EDTSGLLELR STPAAAAAKL GFTAGVIKRE
RMIPFERLLW RVCRGNIYLR YTEMDTTLED PVTREDVKKN VFIIFYQGEQ LKQKIRKICD
GFRATVYPCP ESATERREML DGVNTRIEDL NTVITQTESH RQRLLHEAAA NLWSWGIKVK
KIKAIYHILN CCNIDVTQQC VIAEIWFPVA DAGRIKRALH QGMERSGSTI APILTAIHTR
MAPPTFNRTN KFTAGFQNIV DAYGVGNYRE MNPAPYTIIT FPFLFAVMFG DWGHGAVMLG
FALWMVINEK SLLAQKSTNE IWNTFFSGRY LILLMGIFSM YTGFIYNDCF SKSFNLFGSS
WHIIPMFKNK TWNKDVLLEN TVLQLDPAIP GVYSGNPYPF GIDPIWNVAS NKLTFLNSYK
MKMSVVIGIV HMIFGVVLSL FNHIYFRKYI NIILQFIPEM IFIVSLFGYL VFMIIFKWCR
FDVHSSQSAP SILIHFINMF LFNYSDTSNA PLYLHQKEVQ TFLVIFALIA VPWMLLIKPF
ILRANHQKVQ RMIQSQAMSG NPGDENEVDV PETNHPKKAS QGDHGSGHGG HEDGDEEFDF
GDTFVHQAIH TIEYCLGCIS NTASYLRLWA LSLAHAQLSE VLWTMVMHNG LSNSSWAGLI
VMFVIFAAFA VLTVAILLVM EGLSAFLHAL RLHWVEFQNK FYVGAGHKFS PFSFRHIIDG
TAEE
//
