ID A0A093GCY7_DRYPU Unreviewed; 1026 AA.
AC A0A093GCY7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:KFV64659.1};
DE Flags: Fragment;
GN ORFNames=N307_01657 {ECO:0000313|EMBL:KFV64659.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV64659.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV64659.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV64659.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KL215446; KFV64659.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093GCY7; -.
DR STRING; 118200.A0A093GCY7; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 10.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KFV64659.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 817..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 866..1010
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV64659.1"
FT NON_TER 1026
FT /evidence="ECO:0000313|EMBL:KFV64659.1"
SQ SEQUENCE 1026 AA; 117702 MW; 9DFBD248C7A6324D CRC64;
LLSGSWFPKS LPCDVKASEG TVIVDCTDRR LTEVPRGIPK TATNLTLSIN HITYIYPTSF
AHLINLMEID FRCNCVPVRM GPKDRVCTSK LKIESGSFAS LTRLKSLYLD GNQLLEIPRG
LPTTLSLLSL EANTIFSIKK ANFSELTNLE VLYLGQNCYY RNPCNVSFEI ENTAFLELKK
LTVLSLKSNN LTHIPSNLSS TLKELYIYNN MIQVIQEQDL SALYNLEILD LSGNCPRCYN
APYPCVPCPK STIEIHSKAF YSLKNLRTLR LHSNSLQSIP SSWFKTTRNL KTLDLSQNFL
LKEIGDAQFL KFIPSLVDLD LSFNFEVKMY SPSLNLSKTF SSLTSLETLR VRGYVFKELR
EENLDPLLSL RNLTVLDLGT NFIKVADLRV FRKFPSLKLI DLSVNKISPS SGENSLYGFC
SSPSVSVEQY NRQLLQEMHY FTYDVYGRSC RSKDKEAASY QSPVKQDCLR YGETLDLSRN
NIFFINPSDF RDLSSIRCLN LSDNAISQTL NGSEFSYLSG LKYLDFSNNR VDLLYSTAFQ
ELKLLEILDL SYNKHYFLAE GVTHVLSFMK NLAHLKKLMM NENEISTSSS TGMESQSLQI
LEFRGNRLDV LWRDGNAIYL SFFKNLTSLE HLDISFNSLS FLPRGVFESM PPELRILNLT
NNKMKSFNWG SLQHLKKLET LDLSNNLLTT VPRELSNCSS TLHNLMLRNN RIQELTKHFL
RGAFKLKYLD LSSNNIQIIK KSSFPENVIS NLRMLLLHNN PFKCNCDAVW FVWWINQTQV
TIPLLATDVT CAGPGAHKGK SLVLLDLYTC ELDTSYLIMY ALSASTILGI MVLAVTSHLY
FWDVWYSYHY CAAKLKGYQR FSSPDACYDA FVAYDNEDPA VNEWVMTELV ERLEDQKARQ
FNLCLEERDW LPGQPVFDNL SHSIQLSKKT IFVLTNKYIK SGSFKTTFYM AHQRLLDEKM
DVIILIFLEK VLQKSRYVRL RKRLCRSSVL EWPTNPHSQP YFWQCLKNAI ATSNTLAYNK
LLQETV
//
