ID A0A093GJ31_DRYPU Unreviewed; 533 AA.
AC A0A093GJ31;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:KFV70275.1};
GN ORFNames=N307_14532 {ECO:0000313|EMBL:KFV70275.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV70275.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV70275.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV70275.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; KL216591; KFV70275.1; -; Genomic_DNA.
DR RefSeq; XP_009902678.1; XM_009904376.1.
DR AlphaFoldDB; A0A093GJ31; -.
DR STRING; 118200.A0A093GJ31; -.
DR KEGG; dpub:104303707; -.
DR OrthoDB; 5362214at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR CDD; cd03739; SOCS_SOCS5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR037343; SOCS5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 378..473
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 468..517
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 533 AA; 61166 MW; D3706B1274F19BE5 CRC64;
MDKVGKMWNN FKYRCQNLFS HEGGSQNENI VVNSSSCSPA NEKTIQITDL AQQQPSSPLR
ENIAFQLGLS PSKSSARRNQ NCVTEIPQIV EISIEKENDS CVTTGARLAR RDSYSRHAPW
GWKSCSTKTQ SSLDTEKRFG RTRSGLQRRE RRYGVSSVHD MDVVSNRTVG SRSLRQRLQD
TVGLCFPMRT YSKQSKPLFS NKRKIHLSEL MLEKCPFPAG SDLAQKWHLI KQHTAPVSPH
STFFDTFDPS LVSTEDEEDR LRERRRLSIE EGVDPPPNAQ IHTFEATAQV NPLYKLGPKL
APGMTELTGD KNITPPGNCD SEEDTTTLCL QSRRQKQRQM SGESHGHISR QGAWKVHTQI
DYIHCLVPDL LQITGNPCYW GVMDRYEAEA LLEGKPEGTF LLRDSAQEDY LFSVSFRRYN
RSLHARIEQW NHNFSFDAHD PCVFHSSTVT GLLEHYKDPS SCMFFEPLLT VSLNRTFPFS
LQYICRAVIC RCTTYDGIDD LPLPSMLQDF LKEYHYKQKV RVRWLEREPI KTK
//
