ID A0A093GK34_DRYPU Unreviewed; 1189 AA.
AC A0A093GK34;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Tyrosine-protein phosphatase non-receptor type {ECO:0000256|PIRNR:PIRNR000934};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR000934};
GN ORFNames=N307_08454 {ECO:0000313|EMBL:KFV70640.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV70640.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV70640.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV70640.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR000934};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000934}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649,
CC ECO:0000256|PIRNR:PIRNR000934}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL216602; KFV70640.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093GK34; -.
DR STRING; 118200.A0A093GK34; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR CDD; cd17192; FERM_F1_PTPN21; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF3; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000934};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR000934}; Hydrolase {ECO:0000256|PIRNR:PIRNR000934};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR000934};
KW Receptor {ECO:0000313|EMBL:KFV70640.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875}.
FT DOMAIN 23..312
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 911..1182
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1093..1173
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 321..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1123
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1189 AA; 136040 MW; 56EE2AD6FB68D7A0 CRC64;
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE
ITYFSLWYYN KQNQRRWVDL DKPLKKQLDK YALEPTVYFG VVFYVPTVSQ LQKYQVVFIH
MYQYYLQLKK DILEGNIPCT LEQAIHLAGL AVQADFGDYD QYESQEFLQR FALFPVGWLQ
EEKILEEATQ KVALLHQKYR GLTPPDAEML YMQEVERMEG YGEETYPAKD SQGSDIFIGA
CLDGIFVKHK NGRPPVVFRW HDIANMSHNK SFFALELANK EETIQFQTED METAKYVWRM
CVARHKFYRL NKCSLQTQPV TVNPVRRRSS SRMSMPKPQP YMMPPPPQLH YNGHYTEPYA
SSQDNLFVSN QNGYYCHSQT SLDRAPHDYS GRIRNGSVYS AHSTNSLNNP QHYLQPSPMS
SNPSITGSDV LRTDYVPSHR HSALIPPSYR PTPDYETVMR QLNRGMVHTD RQSHSMRNLN
ISNSYAYSRP DALVYSQPEI REHAHFASPQ SNHYPFNLNY SFHSQSPYPY PTEKRPVVGA
VSVPELTNVQ LQAQDYPAPN IMKTQVYRPP PPYPYPRPAN STPDLSRHIY ISSSNPDLIT
RRVHHSVQTF QEDSLPVAHS LQEVSEPLTS ARHAQLQKRN SIEIAGLTPT FEGIRIKERT
MSASAADVAL PRIISEGSQP NILMERTKQK ESGQEESVNC DHKKTLSDAT MLIHSSEEEE
EFEEESKASS CLSPLPEDQT QLSSVMGGYS HDSVLNYPYS SVASSAGPLH ILEPKLHITE
TEKRMKDMSP PHLLVDSQVQ RRGEGLLTPS MSESDLTTSG RYRVRKDSVK KRPVSDLLSG
KKNIVEGLPP LGGMKKNKND AKKIGPLKLA ALNGLALTRM PLPDEGKEES TRATNDERCK
VLEQRLEQGM VFTEYERIQK KRLRDGECSI ARLPENAERN RFQDVLPYDD TRVELVPTKE
NNTGYINASH IKISVGGIEW DYIATQGPLQ NTCQDFWQMI WEQGIAIIAM VTAEEESGRE
KSFRYWPRLG SRHNTVTYGR FKITTRFRTD SGCYATTGLK IKHLLTGQER TVWHLQYTDW
PEHGCPEDLK GFLSYLEEIQ SVRRHTNSTA DPKSLNPPVL VHCSAGVGRT GVVILSEVMI
SCLEHNEMLD IPRVLDMLRQ QRMMMVQTLS QYTFVYGVLI QFLKSSRLI
//
