ID A0A093GQL2_DRYPU Unreviewed; 684 AA.
AC A0A093GQL2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Double-strand break repair protein MRE11 {ECO:0000256|ARBA:ARBA00017089};
DE Flags: Fragment;
GN ORFNames=N307_08210 {ECO:0000313|EMBL:KFV71622.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV71622.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV71622.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV71622.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MRE11/RAD32 family.
CC {ECO:0000256|ARBA:ARBA00009028, ECO:0000256|RuleBase:RU003447}.
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DR EMBL; KL216874; KFV71622.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093GQL2; -.
DR STRING; 118200.A0A093GQL2; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:InterPro.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.110.110; Mre11, capping domain; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR003701; Mre11.
DR InterPro; IPR038487; Mre11_capping_dom.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR NCBIfam; TIGR00583; mre11; 1.
DR PANTHER; PTHR10139; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR PANTHER; PTHR10139:SF1; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR PIRSF; PIRSF000882; DSB_repair_MRE11; 2.
DR SMART; SM01347; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003447};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003447};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759,
KW ECO:0000256|RuleBase:RU003447};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|RuleBase:RU003447};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003447};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU003447};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|RuleBase:RU003447};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|RuleBase:RU003447};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003447};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875}.
FT DOMAIN 288..459
FT /note="Mre11 DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01347"
FT REGION 485..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 123
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000882-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV71622.1"
FT NON_TER 684
FT /evidence="ECO:0000313|EMBL:KFV71622.1"
SQ SEQUENCE 684 AA; 77395 MW; 253B54E9595A0AEC CRC64;
RDDEDTFKIL IATDIHLGYM EKDPVRGNDT FVTFNEILEQ AQKNEVDFIL LGGDLFHDNK
PSRKTMHCCV ESLRRYCMGD RPVQFEILSD QAVNFQHSKF PLVNYQDPNL NISIPVFSIH
GNHDDPTGAD TLCALDILSC AGLLNHFGRS SSVEKIDISP ILLCKGRTKI ALYGLGSIPD
ERLYRMFLNK KVTMLRPKED EDSWFNLFVL HQNRSKHGAT NYIPEQFLDD FINLVVWGHE
HECKIDPFPN EQQRFYVSQP GSSVVTALSP GEAVKKHIGL LRVRGKKMKM QKIPLETVRT
FHMENVVLAD HPDLFNPDNP KVTQAIQAFC MEKVELMLDS AERERLLNPR QPEKPLIRLR
VISDVKTSGV HKLLVCFVTA ADISKLTEQC FVLECGRLPL CFALPDSDIN FGRLVARPAS
EGMTLRVEDL VKQYFQTAEK KVQLSLLTER GMGEAVQEFV DKEEKDAIEE LVKFQLEKTQ
RFLKERRTEA EEEKIDEEVR KFRESRKKNT EEEDEEVREA ITRARAHRSE DAVLGAASSD
EDMDTSMKGT GDSDDSLPAT LTKGRGRARG RARGARGQSS RGSSRRGRGS TGQESATSSR
TYKPVSVPSK NMSIMDAFRS FKPEASLNSS KAYSEEIIDD DSDIEEISIA PSSRVNKRLS
TTASFSKRPS QIQTSRGVDF ESDE
//