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Database: UniProt
Entry: A0A093GQL2_DRYPU
LinkDB: A0A093GQL2_DRYPU
Original site: A0A093GQL2_DRYPU 
ID   A0A093GQL2_DRYPU        Unreviewed;       684 AA.
AC   A0A093GQL2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Double-strand break repair protein MRE11 {ECO:0000256|ARBA:ARBA00017089};
DE   Flags: Fragment;
GN   ORFNames=N307_08210 {ECO:0000313|EMBL:KFV71622.1};
OS   Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX   NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV71622.1, ECO:0000313|Proteomes:UP000053875};
RN   [1] {ECO:0000313|EMBL:KFV71622.1, ECO:0000313|Proteomes:UP000053875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV71622.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the MRE11/RAD32 family.
CC       {ECO:0000256|ARBA:ARBA00009028, ECO:0000256|RuleBase:RU003447}.
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DR   EMBL; KL216874; KFV71622.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093GQL2; -.
DR   STRING; 118200.A0A093GQL2; -.
DR   Proteomes; UP000053875; Unassembled WGS sequence.
DR   GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR   GO; GO:0008296; F:3'-5'-DNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0004520; F:DNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   CDD; cd00840; MPP_Mre11_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.30.110.110; Mre11, capping domain; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR003701; Mre11.
DR   InterPro; IPR038487; Mre11_capping_dom.
DR   InterPro; IPR007281; Mre11_DNA-bd.
DR   InterPro; IPR041796; Mre11_N.
DR   NCBIfam; TIGR00583; mre11; 1.
DR   PANTHER; PTHR10139; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR   PANTHER; PTHR10139:SF1; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF04152; Mre11_DNA_bind; 1.
DR   PIRSF; PIRSF000882; DSB_repair_MRE11; 2.
DR   SMART; SM01347; Mre11_DNA_bind; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003447};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003447};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759,
KW   ECO:0000256|RuleBase:RU003447};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|RuleBase:RU003447};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003447};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU003447};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|RuleBase:RU003447};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|RuleBase:RU003447};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU003447};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053875}.
FT   DOMAIN          288..459
FT                   /note="Mre11 DNA-binding"
FT                   /evidence="ECO:0000259|SMART:SM01347"
FT   REGION          485..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          655..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        485..530
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..608
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        655..677
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        123
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000882-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFV71622.1"
FT   NON_TER         684
FT                   /evidence="ECO:0000313|EMBL:KFV71622.1"
SQ   SEQUENCE   684 AA;  77395 MW;  253B54E9595A0AEC CRC64;
     RDDEDTFKIL IATDIHLGYM EKDPVRGNDT FVTFNEILEQ AQKNEVDFIL LGGDLFHDNK
     PSRKTMHCCV ESLRRYCMGD RPVQFEILSD QAVNFQHSKF PLVNYQDPNL NISIPVFSIH
     GNHDDPTGAD TLCALDILSC AGLLNHFGRS SSVEKIDISP ILLCKGRTKI ALYGLGSIPD
     ERLYRMFLNK KVTMLRPKED EDSWFNLFVL HQNRSKHGAT NYIPEQFLDD FINLVVWGHE
     HECKIDPFPN EQQRFYVSQP GSSVVTALSP GEAVKKHIGL LRVRGKKMKM QKIPLETVRT
     FHMENVVLAD HPDLFNPDNP KVTQAIQAFC MEKVELMLDS AERERLLNPR QPEKPLIRLR
     VISDVKTSGV HKLLVCFVTA ADISKLTEQC FVLECGRLPL CFALPDSDIN FGRLVARPAS
     EGMTLRVEDL VKQYFQTAEK KVQLSLLTER GMGEAVQEFV DKEEKDAIEE LVKFQLEKTQ
     RFLKERRTEA EEEKIDEEVR KFRESRKKNT EEEDEEVREA ITRARAHRSE DAVLGAASSD
     EDMDTSMKGT GDSDDSLPAT LTKGRGRARG RARGARGQSS RGSSRRGRGS TGQESATSSR
     TYKPVSVPSK NMSIMDAFRS FKPEASLNSS KAYSEEIIDD DSDIEEISIA PSSRVNKRLS
     TTASFSKRPS QIQTSRGVDF ESDE
//
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