ID A0A093GS04_DRYPU Unreviewed; 1097 AA.
AC A0A093GS04;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 27.
DE SubName: Full=Retinoblastoma-like 2 {ECO:0000313|EMBL:KFV69792.1};
DE Flags: Fragment;
GN ORFNames=N307_12475 {ECO:0000313|EMBL:KFV69792.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV69792.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV69792.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV69792.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; KL216479; KFV69792.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093GS04; -.
DR STRING; 118200.A0A093GS04; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20606; CYCLIN_RBL2; 1.
DR CDD; cd00043; CYCLIN_SF; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF8; RETINOBLASTOMA-LIKE PROTEIN 2; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..88
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 51..193
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 371..563
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 802..888
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 983..1097
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 604..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV69792.1"
FT NON_TER 1097
FT /evidence="ECO:0000313|EMBL:KFV69792.1"
SQ SEQUENCE 1097 AA; 124455 MW; C464E564617AA1D5 CRC64;
QRYEELCSSL NMDERARSEA WLSYQSMKLN YTLEGNDLHW LACALYVACR KAVPTVSRGT
AEGNYVSLTR ILRCSEQSLI EFFNKMKKWE DMANLPSQFR ERTERLERNF TVSAVIFKKY
EPIFQDMFRY PQEDQPRQQR GRKQRRQPCT VGDVFQFCWV LFVHAKGNFP MISDDLVNSY
HLLLCALDLV YGNALQCPNR KELLNPNFKG LPEDFHSKDY KVSPDPPCVI EKLCSLHYGL
VLEAKGIKEH FWKPYIRKLF DKKLLKGKDE NLTGFLDPGN FGDSFKAINK AYEEYVLSVG
NLDERIFLGD DADEEIGTLT RCLNTTSGME TAERVQVKDN LQQHFDRSKS LRITTPLTGR
KYIKESNPYV TPISTATYSL SRLHTMLAGL KNAPSENLEQ ILRACSRDPS QSIANRIKDM
SEVYCQSMQA EGEFSNFSKD VVSKHFRRAE VLYYKVLESI IEHEKKTLGD ADLSAILEQD
VFHRSLLACC LEIITFTYKP PGNFPFITEI FDIPVYHFYK VIEVFIRAEN GLCREVVKHL
NHIEEQILES MAWKQESILW DRIRENENKV PTCEEVMPPQ YFERSAGNSV VGSPLTPRRI
NEVRAETGGL GKGLSSSPTT LYDRYSSPTA NPTRRRLFAD NDSPSDSGTA GRVPQQPVVS
TVPVQNMNPE AVSVTPVPGQ TLVTVATATV TANNGQTVTI PVQGIANENG GITFFPVQVN
VGTQPQAVSG PIQPLSAQTL AGTLNTQMTG ATLQVPGQLT VQQISPGEQK QMQQVTTATS
TRPRKMGSLA LFFRKVYHLA SVRLRDLCVK LDIADELRKK IWTCFEYSLV HCPEIMMDRH
LDQLLMCAIY VMAKVTKEDQ SFQNIMRCYR TQPQAKSHVY RSVLIKGKRL RCRSGSADSS
SQQSSPTDRS KEMNKERTSR DSSPVMRSSS TLPVPHPNSA PPTPTRLTGP NSDTEEEERG
DLIQFYNNIY IEQIKEFALK YTLSAQADSP PLSPYPFVRI SSPRRVQLSQ NHPIYISPHK
NESALSPREK IFYYFSSSPS KRLKEINSMV RTGETPTKKR GILLEDGTEA PAKRICQENH
TALIRRLQDV ANDRGSH
//
