ID A0A093GUX3_DRYPU Unreviewed; 1069 AA.
AC A0A093GUX3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=phosphatidylinositol-4,5-bisphosphate 3-kinase {ECO:0000256|ARBA:ARBA00012010};
DE EC=2.7.1.153 {ECO:0000256|ARBA:ARBA00012010};
DE Flags: Fragment;
GN ORFNames=N307_06237 {ECO:0000313|EMBL:KFV70614.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV70614.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV70614.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV70614.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836,
CC ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153;
CC Evidence={ECO:0000256|ARBA:ARBA00023981};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21293;
CC Evidence={ECO:0000256|ARBA:ARBA00023981};
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004805}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; KL216601; KFV70614.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093GUX3; -.
DR STRING; 118200.A0A093GUX3; -.
DR UniPathway; UPA00220; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:InterPro.
DR GO; GO:0046934; F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:InterPro.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd08693; C2_PI3K_class_I_beta_delta; 1.
DR CDD; cd00872; PI3Ka_I; 1.
DR CDD; cd05173; PI3Kc_IA_beta; 1.
DR Gene3D; 3.10.20.770; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR003113; PI3K_ABD.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR000341; PI3K_Ras-bd_dom.
DR InterPro; IPR037702; PI3Kbeta_dom.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10048:SF33; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF02192; PI3K_p85B; 1.
DR Pfam; PF00794; PI3K_rbd; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00143; PI3K_p85B; 1.
DR SMART; SM00144; PI3K_rbd; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51544; PI3K_ABD; 1.
DR PROSITE; PS51546; PI3K_RBD; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFV70614.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 23..112
FT /note="PI3K-ABD"
FT /evidence="ECO:0000259|PROSITE:PS51544"
FT DOMAIN 191..283
FT /note="PI3K-RBD"
FT /evidence="ECO:0000259|PROSITE:PS51546"
FT DOMAIN 327..494
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 523..700
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 771..1052
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV70614.1"
FT NON_TER 1069
FT /evidence="ECO:0000313|EMBL:KFV70614.1"
SQ SEQUENCE 1069 AA; 122432 MW; 502B178C0F2691E8 CRC64;
DFIMPPAVTD SLDIWAVDSQ IGADGSISVD FLLPTGIYIN LDVPRDATIS HIKQLLWKQA
HSYPLFHLLM EIDSYMFSCV NQTAVHEELE DETRRLCDVR PFLPVLKLVT RNCDPGEKLD
SKIGVLIGKG LHEFDTLQDP EVNDFRTKMR RISEEKIQSL VGLSWMDWLK HTYPPEQEPV
IPESFQDKLY SGNLVVAVHF DNCQDVFSFQ VSPNMNPIKL NELAIRKRLT IHGKEDEEVE
PADYVLQVSG RLEYVFGDHP LIQFQYIRNC VMNRTLPQLT LVECCTIKKM CEQEMIAIEA
AINRKSSNLP LPLPPKKTRA TTSVWDISNP FKITLLKGNK LNTEENAKVH VRAGLFHGTE
LLCKTVVSTE ISGRSDHVWN EVLEFEINVC DLPRMARLCF AVYAVMDKMK TKKSTKAMNP
SKYQTIRKAG KVHYPVAWVN TMVFDYKGQL KNGELVLHSW SSFPDELEEM LNPMGTVQTN
PYTENATALH IRFQEYSKQP IHYPPFDKIL EKAAEIARSS DNAAMAGRGG KKFYVVLKEI
MERDPLSQLC ENEMDLIWTL RYDCRENFPQ SLPKLLLSLK WNKLEDVAQL QALLQIWPKL
LPREALELLD FNYPDQYVRE YAVGCLKQMS DEELSQYLLQ LVQVLKYEPF LDCALSRFLL
ERALANRRIG QMLFWHLRSE VHIPAVSVQF GLILEAYCRG SVAHMKVLAK QVEALNKMKT
LNSLIKLNAM KQSKAKGKDA MHTCLKQNAY REALSDLQSP LNPSVILSEL HVEKCRYMDS
KMKPLWIVYN NKMFGGDLVG IIFKNGDDLR QDMLTLQILR LMDILWKEAG LDLRILPYGC
LATGDHSGLI EAVSSSETIA DIQLNSSNVA AAAAFNKDAL LNWLKEYNLG DDLDRAIEEF
TLSCAGYCVA TYVLGIGDRH SDNIMVRKNG QLFHIDFGHI LGNFKSKFGI KRERVPFILT
YDFIHVIQQG KTGNTEKFGR FRQYCEEAYL ILRKHGNLFI TLFALMLTAG LPELTSVKDI
QYLKDSLALG KSEEEALKQF KQKFDEALRE SWTTKVNWMA HTVRKDYRS
//
