ID A0A093H1Z0_STRCA Unreviewed; 636 AA.
AC A0A093H1Z0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Macoilin {ECO:0000256|ARBA:ARBA00021882};
DE AltName: Full=Transmembrane protein 57 {ECO:0000256|ARBA:ARBA00031129};
DE Flags: Fragment;
GN ORFNames=N308_09423 {ECO:0000313|EMBL:KFV73112.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV73112.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV73112.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV73112.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the regulation of neuronal activity.
CC {ECO:0000256|ARBA:ARBA00003440}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004269}.
CC -!- SIMILARITY: Belongs to the macoilin family.
CC {ECO:0000256|ARBA:ARBA00008298}.
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DR EMBL; KL205698; KFV73112.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093H1Z0; -.
DR STRING; 441894.ENSSCUP00000000439; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR InterPro; IPR019130; Macoilin.
DR PANTHER; PTHR47464; MACOILIN; 1.
DR PANTHER; PTHR47464:SF2; MACOILIN; 1.
DR Pfam; PF09726; Macoilin; 1.
DR SUPFAM; SSF46579; Prefoldin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 180..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 356..523
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 565..592
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 221..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV73112.1"
FT NON_TER 636
FT /evidence="ECO:0000313|EMBL:KFV73112.1"
SQ SEQUENCE 636 AA; 73037 MW; 4855FD68B18E54BC CRC64;
STFLYLKFLV VWALVLLADF VLEFRFEYLW PFWLFIRSVY DSFRYQGLAF SVFFVCVAFT
SNIICLLFIP IQWLFFAAST YVWVQYVWHT ERGVCLPTVS LWILFVYIEA AIRFKDLKNF
HVDLCRPFAA HCIGYPVVTL GFGFKSYVSY KMRLRKQKEV QKENEFYMQL LQQALPPEQQ
MLQRQEREAE EGKGLSDMDP SILLQHNGGI PANKKLSSAT LPELEYREKG KEKDKDAKKH
NLGINNNILQ PVDSKIQEIE YMENHINSKR LNNDLVGSTE NLLKEDSCTA SSKNYKNVSG
VVNSSPRSHS ATNGSIPSSS TKNEKKQKCA SKSPSTHKDL MENCIPNNQL SKPDALVRLE
QDIKKLKADL QASRQIEQEL RSQISSLTNT ERGIRSEIGQ LRQENELLQN KLHNAVQMKQ
KDKQMISQLE KKLKAEQEAR AFVEKQLMEE KKRKKLEEAS AARAVAFAAT RGECTETLRN
RIRELETECK KLTIDIKLKE DQIRELEMKV QELRKYKENE KDTEVLMSAL SAMQDKTQHL
ENSLSAETRI KLDLFSALGD AKRQLEIAQG QIIQKDQEIK DLKQKIAEVM AVMPSITYTA
ATSTLSPVSP HYSSKFVETS PSGLDPNASV YQPLKK
//
