ID A0A093H3I6_DRYPU Unreviewed; 512 AA.
AC A0A093H3I6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Frizzled-3 {ECO:0000313|EMBL:KFV73950.1};
DE Flags: Fragment;
GN ORFNames=N307_13649 {ECO:0000313|EMBL:KFV73950.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV73950.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV73950.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV73950.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; KL217139; KFV73950.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093H3I6; -.
DR STRING; 118200.A0A093H3I6; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd07449; CRD_FZ3; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041769; FZ3_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF22; FRIZZLED-3; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 190..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..122
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 185..492
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DISULFID 14..75
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 22..68
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 89..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV73950.1"
FT NON_TER 512
FT /evidence="ECO:0000313|EMBL:KFV73950.1"
SQ SEQUENCE 512 AA; 58998 MW; 9A55DE647287BA7A CRC64;
ILVGHTRGHS LFSCEPIILR MCQDLPYNTT FMPNLLNHYD QQTAALAMEP FHPMVNLECS
RDFRPFLCAL YAPVCMEYGR VTLPCRRLCQ RAYSECSKLM EMFGVSWPED MECTRFPDCD
EPYPRLVDLN LAGEPTEEVP VAVQRDYGFW CPRELKIDPD LGYSFLRVRD CSPPCPNMYF
RREELSFARY FIGVISIVCL SATLFTFLTF LIDVTRFRYP ERPIIFYAVC YMMVSLIFFI
GFLLEDRVAC NASSPAQYKA STVTQGSHNK ACTMLFMVLY FFTMAGSVWW VILTITWFLA
AVPKWGSEAI EKKALLFHAS AWGIPGTLTI ILLAMNKIEG DNISGVCFVG LYDVDALRYF
VLAPLCLYVV VGVSLLLAGI ISLNRVRIEI PLEKENQDKL VKFMIRIGVF SVLYLVPLLV
VIGCYFYEQA YRGVWETTWI QERCREYHIP CPYQVTQMSR PDLILFLMKY LMALVVGIPS
VFWVGSKKTC FEWASFFHGR RKKECVLVAN RI
//
