ID A0A093H5J9_DRYPU Unreviewed; 841 AA.
AC A0A093H5J9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Axin-1 {ECO:0000256|ARBA:ARBA00013892};
DE AltName: Full=Axis inhibition protein 1 {ECO:0000256|ARBA:ARBA00032466};
GN ORFNames=N307_01585 {ECO:0000313|EMBL:KFV74317.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV74317.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV74317.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV74317.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KL217169; KFV74317.1; -; Genomic_DNA.
DR RefSeq; XP_009906225.1; XM_009907923.1.
DR AlphaFoldDB; A0A093H5J9; -.
DR STRING; 118200.A0A093H5J9; -.
DR KEGG; dpub:104306909; -.
DR OrthoDB; 4256282at2759; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd11582; Axin_TNKS_binding; 1.
DR CDD; cd08707; RGS_Axin; 1.
DR Gene3D; 1.10.196.10; -; 2.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR043581; Axin-like.
DR InterPro; IPR014936; Axin_b-cat-bd.
DR InterPro; IPR032101; Axin_TNKS-bd.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46102; AXIN; 1.
DR PANTHER; PTHR46102:SF3; AXIN-1; 1.
DR Pfam; PF16646; AXIN1_TNKS_BD; 1.
DR Pfam; PF08833; Axin_b-cat_bind; 1.
DR Pfam; PF00778; DIX; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00021; DAX; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 88..211
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 759..841
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 94395 MW; CFA71D545351EB6F CRC64;
MNIQGKGFPL DLGGSFTEDA PRPPVPGEEG ELVSTDPRPV SHGFYSSKSD VVRNETSTAT
PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIN LFRTFLKQED CADLLDFWFA
CSGFRKLEPC VSNEEKRLKL AKAIYKKYIL DNNGIVSRQI KPATKSFIKD CVMKLQIDPD
MFDQAQTEIQ CMIEDNTYPL FLKSDIYLEY TRTGGESPKI YSDPSSGSGT GKGLPGYLPT
LNEDEEWKCD QEAEPEANRD SAPSSRLTQK LLLETVPQRA ASARRYSEGR EFRHGSWREP
VNPYYVNTGY ALAPATSAND SEQQSMSSDA DTMSLTDSSV DGIPPYRLRK QHRREMQESA
KANGRVPLPH IPRTYRMPKD IHVEPEKFAA ELINRLEEVQ REREAEEKLE ERLKRVRAEE
EGEDADVSSG PSVLSHKMPS AQAFHHFAPR YAEMGCAGMQ MRDAHEENPE SILDEHVQRV
MKTPGCQSPG PGRHSPKPRS PESGHLGKLA GTLGTAPPGH GKHATKSGMK LDAANLYHHK
HIYHHIHHHS GMKPKEQIEA EATQRVQSSF AWNVDPHNYA TKARNYTESL GMAPGPMDSL
GYSGKASLLS KRNGKKTDSG KSDGANYEMP GSPEDVERNQ KILQWIIEGE KEISRHKKTN
HGSSGAKKQL SHDVGRPLSI ERPVAVHPWV SAQLRNVVQP SHPFIQDPTM PPNPAPNPLT
QLEEARRRLE EEEKRAGKLP PKQRLKPQKR PGSGTSQPCE NIVVAYYFCG EPIPYRTLVK
GRVVTLGQFK ELLTKKGNYR YYFKKVSDEF DCGVVFEEVR EDDTILPIFE EKIIGKVEKI
D
//
