ID A0A093HKL1_GAVST Unreviewed; 948 AA.
AC A0A093HKL1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Integrin alpha-V {ECO:0000313|EMBL:KFV55123.1};
DE Flags: Fragment;
GN ORFNames=N328_07163 {ECO:0000313|EMBL:KFV55123.1};
OS Gavia stellata (Red-throated diver) (Colymbus stellatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Gaviiformes; Gaviidae; Gavia.
OX NCBI_TaxID=37040 {ECO:0000313|EMBL:KFV55123.1, ECO:0000313|Proteomes:UP000054313};
RN [1] {ECO:0000313|EMBL:KFV55123.1, ECO:0000313|Proteomes:UP000054313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N328 {ECO:0000313|EMBL:KFV55123.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK629826; KFV55123.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093HKL1; -.
DR Proteomes; UP000054313; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF4; INTEGRIN ALPHA-V; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000054313};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 894..916
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 47..108
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 139..193
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 194..259
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 260..317
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 321..384
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 369..525
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 526..655
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 672..883
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 927..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV55123.1"
FT NON_TER 948
FT /evidence="ECO:0000313|EMBL:KFV55123.1"
SQ SEQUENCE 948 AA; 105450 MW; 130451E723EA454F CRC64;
RIFLLVGAPK ANTTQHNIVE GGQVLKCNWD SNRNCQPIIF DSTGNRDFAP DDPLEFKSHQ
WFGASVRSKN DKILACAPLY HWRTETKQER EPVGTCYLLA GSKSVEYAPC RSSQLISDRV
TEIVAKYDSK VYSTKYDDQL ATRPASAAFD DSYLGYSVAV GDFNGDGIED FVSGVPRAAR
TLGMVSIYNG KNMSSMYNFT GEQMAAYFGY SVAAADINGD NYTDLFIGAP LFMDRGSDGK
LQEVGQVSIC LQRASGGFQI TKLNGFEIFA RFSSSIAPLG DLDQDGFNDI AVAAPYGGED
KRGLVYIYNG RANGLNAVPS QILEGQWATR TMPPSFGYSL KGATDVDKNG YPDLIVGAFG
VDTAVLYRAR PVIRVNAALE VNPTILNPEN KACSLSDVKV SCFKVKFCLK ADGKGKLPNS
LNFQVELLLD KLKQKGAIRR ALFLHSKQPS HSKNMTITKG GKMNCEELDA FLRDESEFRD
KLTPITIFME YRLDYRTAAD ATGLHPILNQ FTPANMSRQA HILLDCGDDN VCKPKLEVSV
ESDQKQIYIG DDNPLTLIVS AQNQGEGAYE AELFVIVPPQ ADFIGVVRNN EALARLSCAF
KTENQTRMVV CDLGNPMKAG TKLLAGLRFS VHQQSEMDTS VKFDLQIRSS NLYDNLSPIA
FYQADLAILA AVEIRGVSSP DHIFLPIANW QPKENPETED DIGPLVQHIY ELRNNGPSAF
SKVMMTLQWP YKYKNYTLLY IVQYEIDGPM NCTSDMEINP LKIKISASKD DDKNETLSRE
DNRDHHISRR DITAIEGDVH TLGCGTADCL KIVCQVGHLE RGKSAILYLK SRLWTQTFMN
QENQNHSYSL KSSASFNVIE FPYKNLSFED IHNSTVVTTN ITWGIQPQPM PVPVWVIILA
VLAGLLLLAV LVFVMYRMGF FKRVRPPQEE QEREQLQPHE NGEGTSEA
//
