ID A0A093HXA6_STRCA Unreviewed; 1852 AA.
AC A0A093HXA6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 40.
DE SubName: Full=Myotubularin-related protein 5 {ECO:0000313|EMBL:KFV86271.1};
DE Flags: Fragment;
GN ORFNames=N308_15364 {ECO:0000313|EMBL:KFV86271.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV86271.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV86271.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV86271.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; KL206838; KFV86271.1; -; Genomic_DNA.
DR STRING; 441894.ENSSCUP00000023892; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd13340; PH-GRAM_MTMR5; 1.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR CDD; cd14588; PTP-MTMR5; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF43; MYOTUBULARIN-RELATED PROTEIN 5; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584}.
FT DOMAIN 1..413
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1091..1567
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1746..1850
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 78..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1696..1737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV86271.1"
FT NON_TER 1852
FT /evidence="ECO:0000313|EMBL:KFV86271.1"
SQ SEQUENCE 1852 AA; 209107 MW; C35DDD1D1CCC6ED0 CRC64;
SAGSGDGQGQ ILQRFPEKDW EDNPFPQGIE LFCQPSGWQL FTERNPPTFF IAVLTDINSE
RHYCACFTFW EAVESAQNHS RNGEGEEEEE ESSSPVQPAQ LFAPKSLVLV SRLDHAEVFR
NSLGLIYTIY VDGLSVSLEN VIGNLLTCTI PITGGAQRTI SLGAGDRQVI QTPINDSLPV
SSCSVALLFR QLGITNVLYL FCAALTEHKI LFLSSSYQRL TDACRALLAL MFPLKYSFTY
VPILPAQLLE VLSTPTPFII GVHSIFQSET QELLDVVIAD LDGGTVNVPE CVHISLLPEP
LLQQTREALS MVLDPELEVA DLAFPPSTVS ASSLKMQDKE IRAVFLRLFA QLLQGYRWCL
HIIRIHPEPV IRFHKAAFLG QRGLTEDDFL TKVLEGMAFA GFVTERGAPY RSIDLFDELV
AYEVKRMRAE EGNKQKILRH IKELAEKLYK NENPYPAVTM HKVQKPTEGC HLRLHQKPFP
RLDEGTVQWI IDQATAKLQT APPAVKAEKK CMVPSGPPIA AIMERNGNAL ANSARRLEVV
RNCISYVFEN KMLEAKKLFP AVLRAMKGRA ARHCLTQELN LHVQQNRAVL DHQQFDFVVR
MMNCCLQDCT AMDEHGIAAA LLPLVTAFCR KLSPGITQFA YSCVQEHVVW TNIQFWEAMF
YCDVQNHIRA LYLDNNEENH TDEESKEGPQ EVKSALEIAS EQLRLWPTMS REKQQELIQK
EESTVFSQAI HYANRMSYLL LPLDTSKNRL LRSSGLGDVE SVSNSFVTNS IAGSVAESYD
TESGFEDAES SDVANYVVRF INRFVDKVCT ESGVTNEHLK GLHVMIPDIV QMHIETLDAV
HRESKRLPPI QKPKLLRPNL LVGEECVMEG LRVYLMPDGR EEAAGGNIGG PPLLPAEGAI
FLTTYRIIFK GTPTDPLVGE QVVIRSFPIA SLTKEKKINI QAQVDQFIQE GLQLRSCTFQ
LLKIAFDEEV ASESAEVFRK HLHKLRYPQH VRGTFAFTVG QSPKQAMQPK AKEKNPSLRT
LSKNLVKNAK KTIGRQYVTR KKYTPPAWEQ RSSQHFSEDN EDEISVSEEM DRSTLTSTTT
IKPSDKMTIN HLVERACCRD YQRMGLGTLS SSLTRSKNEP FRISTVNRMY AICRSYPGLL
IVPQSIQDNT IQRISRCYRQ NRFPVVCWRN SRTKAVLLRS GGLHGKGVVG LFKSQNAPSA
GPSQTDSTSL EQEKYLQAVI NSMPHYADAS GRNTLSGFTS AHMSSSGKWG SIRASGRMSS
YALNMEIGSR LAGKDLLSAQ HNGAPSEASF LRQHRASLYI IGDKSQLKGV KPDPLQHWEV
VPIEVFDVRQ VKASFKKLMK ACVPGCPSTD PSVAYLRSLE ESEWLSQIHK ILQISVLVVE
LLDTGSSVLV SLEDGWDITT QVVSLVQLLS DPYYRTMEGF RLLVEKEWLS FGHRFSHRGA
QTLAGQSSGF APIFLQFLDC VHQIHLQFPM EFEFSQYYLK FLSYHYISNR FRTFLLDSDY
ERIELGLLYE EKGERKSQQV YKSIWDYIDR LNKKAPIFFN YMYAPEDGEV LRPYSNISNL
KVWDYYTEET LSEGPSYDWE LVQGQPEHME EADRQDTSAP QTKRKIIWPC YDNRSRVEPD
AISKLLEELH NLEMELGQVP ERWKDTWDKV KASQRTEARQ EGSRTPSSLL MSSGLSHHRR
SLGVYLQESG VGSTLNLSLD SDTSSTSTPS SGKQGGRKST STLYSQFQMS ESENRQAEGA
EGTGGCWSYE GSLYKKGAFM KPWKPRWFVL DKTKHQLRYY DSRMDTECKG VIDLAEVESI
TPGTPTMGAP KTVDEKAFFD LKTTKRVYNF CAQDVQLAQQ WIDRIQSCLS DA
//
