ID A0A093HZI2_STRCA Unreviewed; 378 AA.
AC A0A093HZI2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=acetyl-CoA C-acetyltransferase {ECO:0000256|ARBA:ARBA00012705};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
DE Flags: Fragment;
GN ORFNames=N308_04104 {ECO:0000313|EMBL:KFV88178.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV88178.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV88178.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV88178.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; KL206991; KFV88178.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093HZI2; -.
DR STRING; 441894.ENSSCUP00000024740; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919:SF171; ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KFV88178.1}.
FT DOMAIN 1..249
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 257..378
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 74
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 335
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 365
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV88178.1"
FT NON_TER 378
FT /evidence="ECO:0000313|EMBL:KFV88178.1"
SQ SEQUENCE 378 AA; 39592 MW; 04E8630EB853F698 CRC64;
GSFNGGLSTM HAHELGAVVI REALKRASIN PEEVSEVILG QVLAAGAGQN PVRQASVGAG
IPYSVPAWSC QMICGSGLKA VCLAAQSILM GDSSIVVAGG MESMSKAPHI IHMRAGVKMG
EVSLQDSIIH DGLTDAFYQY HMGITAENVA NQWQVSRAEQ DQCAVWSQNR AEAAQKAGYF
AKEIVPVLVP SKKGPIEVKI DEHPRHGSNL ETMAKLKPCF LMDGTGTVTA ANASGMNDGA
AAVILMKKSE AARRGLMPLA RIVSWAQTGL DPSIMGVGPI TAIKQAVDKA GWTLEQVDLF
EINEAFASLS VAITKELEVN PEKVNIQGGA IALGHPLGAS GCRILVTLLY ALERTGGKRG
VAALCIGGGM GIAMCIER
//
