ID A0A093I2S1_STRCA Unreviewed; 488 AA.
AC A0A093I2S1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=CASP8 and FADD-like apoptosis regulator {ECO:0000313|EMBL:KFV86125.1};
DE Flags: Fragment;
GN ORFNames=N308_08471 {ECO:0000313|EMBL:KFV86125.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV86125.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV86125.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV86125.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
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DR EMBL; KL206820; KFV86125.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093I2S1; -.
DR STRING; 441894.ENSSCUP00000022423; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08337; DED_c-FLIP_r1; 1.
DR CDD; cd08340; DED_c-FLIP_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF4; CASP8 AND FADD LIKE APOPTOSIS REGULATOR; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..78
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 97..175
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 271..367
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT NON_TER 488
FT /evidence="ECO:0000313|EMBL:KFV86125.1"
SQ SEQUENCE 488 AA; 56445 MW; 6C2E229626905770 CRC64;
MTKCQVPAAL IHQIEQELDK EEEEIMIFLC RDLAPDLATA DLRELLAGLN EREKLSPFGL
SELLYRVKRF DLLRRILKTE KATVEANLAR CPRLVPDYRV LMVEINENLE KEEVNSLVFL
LRDYAPRMKM TKDKSFLALV IDLEKLNLVA PNQLDLIEDC FRNIHRMDLI KKIQKYKQEA
LMSSVHSQPV YVNALQASLP NLTLIDPPYN SGIQNVNQHK TQNRQSLIQA EPFHLSIQES
GPMLHKVFDD QYRMQSQPLG VCLIIDCIGN DSDMLEETFG DLGYDVHCYR YLNMDTMNQT
LHEIARLQKH RNCDSFICVL VSRGSPQSIF CTDQTFSGFP LEQIKKYFTA DSCPELLGKP
KLFFIQSYIV PESEQECTSL LEVDGNDEKI IANAKIPWKV TIPQVADIFW SQCKVDVSIL
ESSPSPSSYY LRCLAELLRD PHKRKLSVLD IHTELNREVY EWNKTIDPSR QYSLLLQHTL
RKKLFFSP
//
