ID A0A093I673_STRCA Unreviewed; 2841 AA.
AC A0A093I673;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Adenomatous polyposis coli protein {ECO:0000313|EMBL:KFV86697.1};
DE Flags: Fragment;
GN ORFNames=N308_12198 {ECO:0000313|EMBL:KFV86697.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV86697.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV86697.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV86697.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR EMBL; KL206890; KFV86697.1; -; Genomic_DNA.
DR STRING; 441894.ENSSCUP00000025381; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.10; -; 1.
DR Gene3D; 1.10.287.450; Helix hairpin bin; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR032038; APC_N.
DR InterPro; IPR036149; APC_N_sf.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009232; EB1-bd.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607:SF11; ADENOMATOUS POLYPOSIS COLI PROTEIN; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF05972; APC_15aa; 3.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF16689; APC_N_CC; 1.
DR Pfam; PF05923; APC_r; 7.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF16634; APC_u13; 1.
DR Pfam; PF16635; APC_u14; 1.
DR Pfam; PF16636; APC_u15; 1.
DR Pfam; PF16630; APC_u5; 1.
DR Pfam; PF16633; APC_u9; 1.
DR Pfam; PF00514; Arm; 2.
DR Pfam; PF16629; Arm_APC_u3; 1.
DR Pfam; PF05937; EB1_binding; 1.
DR Pfam; PF05924; SAMP; 3.
DR Pfam; PF11414; Suppressor_APC; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF58050; N-terminal coiled coil domain from apc; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 6..57
FT /note="Adenomatous polyposis coli N-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16689"
FT REPEAT 662..704
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 2223..2572
FT /note="Adenomatous polyposis coli protein basic"
FT /evidence="ECO:0000259|Pfam:PF05956"
FT DOMAIN 2668..2841
FT /note="EB-1 binding"
FT /evidence="ECO:0000259|Pfam:PF05937"
FT REGION 98..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1315..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1678..1951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1963..2010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2042..2071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2146..2639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2662..2841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..56
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 136..170
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 99..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1315..1382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1623..1640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1688..1708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1793..1837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1868..1900
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1901..1939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1977..1994
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2169..2190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2199..2225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2233..2274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2282..2425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2460..2506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2516..2530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2554..2577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2588..2605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2621..2639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2667..2681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2718..2773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2784..2811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2821..2841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV86697.1"
FT NON_TER 2841
FT /evidence="ECO:0000313|EMBL:KFV86697.1"
SQ SEQUENCE 2841 AA; 311595 MW; E24B27CFD90FDC62 CRC64;
PRMAAASYDQ LLKQVEALKM ENSNLRQELE DNSNHLTKLE TEASNMKEVL KQLQGSIEDE
AMASSGQIDL LERLKELNLE SSNFPGVKLR PKVSMRSYGS REGSVSSRSG ECSPVPMGSF
PRRGFMNGSR ESTGYLEELE KERSLLLAEL EKEEKEKDWY YAQLQNLTKR IDSLPLTENF
SLQTDMTRRQ LEYEARQIRA AMEEQLGTCQ DMEKRAQVRV ARIQQIEKDI LRIRQLLQSQ
AAEAERTPQS KHDAGSHDTE RQNEGQGAAE TSTATTGTGQ GSAARMDHET ASVMSSSNNY
SVPRRLTSHL GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCIAMR QSGCLPLLIQ
LLHGNDKDSV LLGNSRGSKE ARARASAALH NIIHSQPDDK RGRREIRVLH LLEQIRAYCE
TCWEWQEAHE QGMDQDKNPM PAPVDHQICP AVCVLMKLSF DEEHRHAMNE LGGLQAIAEL
LQVDCEMYGL TNDHYSVTLR RYAGMALTNL TFGDVANKAT LCSMKGCMRA LVAQLKSESE
DLQQVIASVL RNLSWRADVN SKKTLREVGS VKALMECALE VKKESTLKSV LSALWNLSAH
CTENKADICA VDGALAFLVG TLTYRSQTNT LAIIESGGGI LRNVSSLIAT NEDHRQILRE
NSCLQTLLQH LKSHSLTIVS NACGTLWNLS ARNAKDQEAL WDMGAVSMLK NLIHSKHKMI
AMGSAAALRN LMANRPAKYK DANIMSPGSS LPSLHVRKQK ALEAELDAQH LSETFDNIDN
LSPKASHRNK QRHKQNIYSE YVLDANRHDD GICRSESFNT GNVTVLSPYL NTTVLPGSSS
SSRGNTENSR SEKDRNLDRD RAVGLNTYHP GTETTGNSSK RIGMQISTAA AQIAKVMEEV
TSMHIPQEDR SSGSTSEMHC LTEDRNAPRR AATAHTHSNT YFPKAENSNR TCPVPYTKME
YKRASNDSLN SVSSSDGYGK RGQMKPSIES YSEDDESKFC SYGQYPADLA HKIHSANHMD
DNEGELDTPI NYSLKYSDEQ LNSGRQSPSQ NERWARPKHI IDDEIKQNEQ RQSRSQNATY
PVYSESGDDK HMKYQSPFGQ QECVSSFRSR GSSGSDQNRV GSTLGMNQKV NQSLCQVDDY
DDDKPTNYSE RYSEEEQHEE EEDRPTNYSI KYNEEEHHVD QPIDYSLKYS TEVPPSSQKP
SFTFSKSSSV QSTKTDHISS SSGNTSAPSA SSKRQNQLHP SSAQSRGSHA QKTASCKTPS
INQETIQTYC VEDTPICFSR CSSLSSLSSA EDEMGRDQST RVTDANNTLQ IAELKENSGT
LSTEGAVSEV TSTSQHIRTK SSRLQTSSLS PSDSSRHKAV EFSSGAKSPS KSGAQTPKSP
PEHYVQETPL MFSRCTSVSS LDSFESRSIA SSVQSEPCSG MVSGIISPSD LPDSPGQTMP
PSRSKTPPPA QGAQVKREAA KGKVPSAEKR EPGPRQAAVN AAVQRVQVLP DADTLLHFAT
ESTPDGFSCS SSLSALSLDE PFIQKDVELR IMPPVHENEH GNEAEPEQPD DAKDNQEKKA
EKPTEAEKDI LDDSDDDDIE ILEECIISAM PTKSSRKAKK PSQASASKIP PPVARKPSQL
PVYKLLPSQS RLQSQKHVSF TPGDDMPRVY CVEGTPINFS TATSLSDLTI ESPPNELANV
ENVGAGTDSG EFEKRDTIPT EGRSTDDSQR VKSSTVTASG LDDDKTEEGD ILAECINSAM
PKGKSHKPFR VKKIMDQIQQ ASSSLSNKNQ SEGEKKKPTS PVKPAPQNNE YRARIRKNTE
PKSNINNERS YSENRDTKKH LKNNSRDFHD KLPNNEERVR GSFAFDSPHH YTPIEGTPYC
FSRNDSLSSL DFDDDDVDLS REKAELRKGK EAKETESKDC TSSEQSSNQQ PSNRTQVCQK
HPPGRSQPKS FSQSTKEIPD RGAATDEKMQ NFAIENTPVC FSRNSSLSSL SDIDQENNNN
KESEPAKRSE APDSQIESSR PQTSGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE
CISSAMPKKK KPSRVKSESE KNNSRNMGGI LAEDLTLDLR DIQRPDSEHG FSPDSENFDW
KAIQEGANSI VSSLHQAAAA ASLSRQASSD SDSILSLKSG ISLGSPFHLT PDQEEKPFTS
NKGPRILKPG EKSTLESKKV ESENKGIKGG KKVYKSIITG KARSSSEVSS QLKQPQQTSM
PSISRGRTMI HIPGVRNSSS STSPVSKKGP PPKNTNSKSP SEGQSCTSSP RGVKSSVKPE
PAPVTRQPSQ QGGSSKGPSR SGSRDSTPSR PQQQPLSRPL QSPGRNSISP GRNGISPPNK
LSQLPRTSSP STASTKSSSS GRMSYTSPGR QMSQQNLAKQ TALPKSNSGI PRSESASKGL
NQILSSGGSN KKTELSRMSS TKSSGSESDR SERPVLVRQS TFIKEAPSPT LRRKLEESAS
FESLSPSRPD SPTRSQIQTP VLSPSLPDMS LSTHSTAQTS GWRKLPPNLS PSVEYDGRPV
KRHDIARSHS ESPSRLPINR SGTWKREHSK HSSSLPRVST WRRTGSSSSI LSASSESSEK
AKSEDEKQYG SSVSGPKQSK ESQAPAKGTW RKIKENEIPQ IMNDPQHSSS GATNGSDSKT
LIYQMAPAVS KTEDVWVRIE DCPINNPRSG RSPTGNTPPV IDSLSEKGGV NGKDSKESQE
KQNAGNGNVP VRTIGLENRL NSFIQIDSPD KKGTETKPMQ NNAVPAPENN ESTVSERTPF
SSSSSSKHSS PSGAVAARVT PFNYNPSPRK SSADNSSARP SQIPTPVNNS TKKRDSKTEN
TDSSGTQSPK RHSGSYLVTS V
//
