ID   A0A093I9M6_STRCA        Unreviewed;       740 AA.
AC   A0A093I9M6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=N-acetylated-alpha-linked acidic dipeptidase 2 {ECO:0000313|EMBL:KFV88605.1};
GN   ORFNames=N308_04770 {ECO:0000313|EMBL:KFV88605.1};
OS   Struthio camelus australis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC   Struthio.
OX   NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV88605.1, ECO:0000313|Proteomes:UP000053584};
RN   [1] {ECO:0000313|EMBL:KFV88605.1, ECO:0000313|Proteomes:UP000053584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV88605.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC       protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
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DR   EMBL; KL207000; KFV88605.1; -; Genomic_DNA.
DR   RefSeq; XP_009687399.1; XM_009689104.1.
DR   AlphaFoldDB; A0A093I9M6; -.
DR   STRING; 441894.ENSSCUP00000021051; -.
DR   MEROPS; M28.012; -.
DR   Ensembl; ENSSCUT00000027850; ENSSCUP00000021051; ENSSCUG00000015461.
DR   GeneID; 104153279; -.
DR   KEGG; scam:104153279; -.
DR   OrthoDB; 2428249at2759; -.
DR   Proteomes; UP000053584; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd08022; M28_PSMA_like; 1.
DR   CDD; cd02121; PA_GCPII_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR007365; TFR-like_dimer_dom.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   PANTHER; PTHR10404:SF38; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE 2; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   Pfam; PF04253; TFR_dimer; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT   DOMAIN          161..249
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          347..550
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   DOMAIN          617..737
FT                   /note="Transferrin receptor-like dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF04253"
SQ   SEQUENCE   740 AA;  83435 MW;  94673069BD7634AB CRC64;
     MAGSRTTLRM WLGCPGLLGC FLLGLLTGWF TKPTEKATTS ADVYQNVRQK LMAEMKAENI
     KQFLRSFTKF PHLAGTEQNL FLAKQIQGQW KEFGLDSAEL VHYDVLLSYP NETQPNYISV
     IDDQGNEIFN TSLFEPPPQG YENVTGILPP YNAFSAQGML EADLVYVNYG RTEDFFKLER
     EMGINCTGKI VIARYGKIFR GNKVKNAILA GAQGIILYSD PADYCAPGVD VYPDGWNLPG
     GGAQRGNVLN LNGAGDPLTP GYPAKEYTFR YKVKEGVGIP KIPVHPIGYH DAEVLLRAMG
     GPAAPDSSWK GSLNVSYNIG PGFAHHFSTR KVRMHVQTNN KITRIYNVIG ILRGAMEPDR
     YIILGGHRDS WVFGGIDPTT GAAVLQEIVR SFGKMKMEGW RPKRTIIFAS WDAEEFGLLG
     STEWAEENAR VLQERAVAYI NTDSSIEGNY TLRVDCTPLL YKLVYNLTKE ISSPDEGYES
     KSLYESWLEK DPATENNSYP RINKLGSGSD FEAYFQRLGI ASGRVRYTKN RKADKFSNYP
     VYHTVYETFE LVEKFYDPTF RKQLTIAQLR GKLVYELADS YILPFDCRDY GEALKGYSNR
     IYKLAKKHEE QLKTYKVSFD PLFSAVMNFS KAAAEFHRRL EQADMNDPVA VRIMNDQLMF
     IERAFIDPLG LPGRKFYRHV IFAPSSHNKY AGESFPGIYD AMFDIESKAD QRGAWEEVKR
     QISVAAFTVQ AAAETLKEVA
//