ID A0A093IAA2_STRCA Unreviewed; 365 AA.
AC A0A093IAA2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 22.
DE SubName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 2 {ECO:0000313|EMBL:KFV88820.1};
GN ORFNames=N308_06633 {ECO:0000313|EMBL:KFV88820.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV88820.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV88820.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV88820.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL207003; KFV88820.1; -; Genomic_DNA.
DR RefSeq; XP_009687676.1; XM_009689381.1.
DR RefSeq; XP_009687677.1; XM_009689382.1.
DR RefSeq; XP_009687678.1; XM_009689383.1.
DR AlphaFoldDB; A0A093IAA2; -.
DR STRING; 441894.ENSSCUP00000021173; -.
DR Ensembl; ENSSCUT00000028001; ENSSCUP00000021173; ENSSCUG00000015538.
DR GeneID; 104153466; -.
DR KEGG; scam:104153466; -.
DR CTD; 166929; -.
DR OrthoDB; 1343173at2759; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0047493; F:ceramide cholinephosphotransferase activity; IEA:Ensembl.
DR GO; GO:0002950; F:ceramide phosphoethanolamine synthase activity; IEA:Ensembl.
DR GO; GO:0033188; F:sphingomyelin synthase activity; IEA:Ensembl.
DR GO; GO:0046513; P:ceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:1905373; P:ceramide phosphoethanolamine biosynthetic process; IEA:Ensembl.
DR GO; GO:0030500; P:regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0006686; P:sphingomyelin biosynthetic process; IEA:Ensembl.
DR CDD; cd01610; PAP2_like; 1.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF24; PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 2; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KFV88820.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 79..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 221..293
FT /note="Sphingomyelin synthase-like"
FT /evidence="ECO:0000259|Pfam:PF14360"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 31..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 42321 MW; 885E3C829AD681DA CRC64;
MNTIETAKLE EHMEGQNNDT SNGYARPTLS ISEETKNGNS KPKGLSNGLR KSTKKYPDYI
QIAMPAESRN KFPLEWWKTG IAFVYALFNL ILTTVMITVV HERVPPKELS PPLPDKFFDY
IDRVKWAFSV SEINGMILVG LWIFQWLFLR YKSIVGRRFF FIIGTLYLYR CITMYVTTLP
VPGMHFQCAP KLNGDSQAKV QRILRLISGG GLSITGSHIL CGDFLFSGHT VVLTLIYLFI
KEYSPRHFWW YHLICWLMSA AGIVCILVAH EHYTVDVIIA YYITTRLFWW YHSMANEKTL
KVSSQTNFLS RAWWYPIFYF FEKNVQGSVP CSFSWPISWP PSCFKSSCKK YSRVQKTGED
NEKST
//
