ID A0A093IBP4_STRCA Unreviewed; 423 AA.
AC A0A093IBP4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Protein cereblon {ECO:0000256|ARBA:ARBA00014394};
DE Flags: Fragment;
GN ORFNames=N308_15498 {ECO:0000313|EMBL:KFV88577.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV88577.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV88577.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV88577.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CRBN family.
CC {ECO:0000256|ARBA:ARBA00005293}.
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DR EMBL; KL206999; KFV88577.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093IBP4; -.
DR STRING; 441894.ENSSCUP00000020852; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd15777; CRBN_C_like; 1.
DR Gene3D; 1.20.58.1480; -; 1.
DR Gene3D; 2.30.130.40; LON domain-like; 1.
DR Gene3D; 2.170.150.20; Peptide methionine sulfoxide reductase; 1.
DR InterPro; IPR034750; CULT.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR PANTHER; PTHR14255; CEREBLON; 1.
DR PANTHER; PTHR14255:SF4; PROTEIN CEREBLON; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR SMART; SM00464; LON; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS51788; CULT; 1.
DR PROSITE; PS51787; LON_N; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 60..297
FT /note="Lon N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51787"
FT DOMAIN 298..406
FT /note="CULT"
FT /evidence="ECO:0000259|PROSITE:PS51788"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV88577.1"
FT NON_TER 423
FT /evidence="ECO:0000313|EMBL:KFV88577.1"
SQ SEQUENCE 423 AA; 48755 MW; 78DE644148AC42EE CRC64;
ESEEEDDNEM EVEDQDSKEA EKPNIINFDT SLPTSHVYLG SDMEEFHGRT VHDDDSCQVI
PVLPHVMVML IPGQTLPLQL FRPQEVSMVR NLIQKDRTFA VLAYSNVRER EAHFGTTAEI
YAYREEQEFG IETVKVKAIG RQRFKVLEIR TQSDGIQQAK VQILPERVLP STMSAVQLQS
LNRCHVFPSS KPTAWQDRAI HQWWQKYQKR KFHCASLTSW PPWLYSLYDA ETLMERVKRQ
LHEWDENLKD ESLPTNPIDF SYRVAACLPI DDALRIQLLK IGSAVQRLRC ELDIMNKCTS
LCCKQCQDTE ITTKNEIFSL SLCGPMAAYV NPHGYIHETL TVYKACNLNL SGRPSTEHSW
FPGYAWTIAQ CRICGNHMGW KFTATKKDMS PQKFWGLTRS ALLPRIPETE DESGHDRSPL
LCL
//
