ID A0A093ICM5_EURHL Unreviewed; 431 AA.
AC A0A093ICM5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE Flags: Fragment;
GN ORFNames=N326_10240 {ECO:0000313|EMBL:KFW00465.1};
OS Eurypyga helias (Sunbittern) (Ardea helias).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Eurypygiformes;
OC Eurypygidae; Eurypyga.
OX NCBI_TaxID=54383 {ECO:0000313|EMBL:KFW00465.1, ECO:0000313|Proteomes:UP000054232};
RN [1] {ECO:0000313|EMBL:KFW00465.1, ECO:0000313|Proteomes:UP000054232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N326 {ECO:0000313|EMBL:KFW00465.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00000251,
CC ECO:0000256|RuleBase:RU610713};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC {ECO:0000256|ARBA:ARBA00008871, ECO:0000256|RuleBase:RU610713}.
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DR EMBL; KK559716; KFW00465.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093ICM5; -.
DR Proteomes; UP000054232; Unassembled WGS sequence.
DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR018155; Hyaluronidase.
DR PANTHER; PTHR11769; HYALURONIDASE; 1.
DR PANTHER; PTHR11769:SF9; HYALURONIDASE; 1.
DR Pfam; PF01630; Glyco_hydro_56; 1.
DR PIRSF; PIRSF038193; Hyaluronidase; 1.
DR PRINTS; PR00846; GLHYDRLASE56.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU610713};
KW Hydrolase {ECO:0000256|RuleBase:RU610713};
KW Reference proteome {ECO:0000313|Proteomes:UP000054232}.
FT ACT_SITE 127
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
FT CARBOHYD 349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-2"
FT DISULFID 39..332
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 203..219
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 357..368
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 362..419
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW00465.1"
FT NON_TER 431
FT /evidence="ECO:0000313|EMBL:KFW00465.1"
SQ SEQUENCE 431 AA; 49527 MW; 9B7799AE0272EA38 CRC64;
LAVAALLIMV DAQLSKPARA PLALHKPFMV VWNAPTEQCR LRYKVDLDLS VFDIVSNTNE
TLSGSNVTIF YHTHLGYYPY YSDNGDPVNG GVPQNESLLK HLHKAKSDID YCIPMKKFQG
LAVIDWENWR PQWDRNWGNK SIYRNKSLEI VRRRHPQWSE DKIRKVAKEE FENAGKSFMN
NTILLAEHMR PNGLWGYYLY PDCYNYDYKE QPQTYTGKCP AIESSRNDLL LWLWKESTAL
YPSIYLDYIL KSSPNALKFV HFRVKEAIRV ASIARKDYVL PVFVYSRPFY AYTFNVLTEM
DLVNTIGESA ALGAAGVVLW GSMQYASSKE SCSTVKRYID GPLGHYVINV TSAAKLCSKV
LCKKNGRCIR KNSDSSAYLH LSPTDFKIRV RHSERGPQFQ VTGEPSLESI EAMRQRFMCQ
CYQGWTGIFC E
//
