ID A0A093IE63_DRYPU Unreviewed; 609 AA.
AC A0A093IE63;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
DE Flags: Fragment;
GN ORFNames=N307_15007 {ECO:0000313|EMBL:KFV65041.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV65041.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV65041.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV65041.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MPEG1 family.
CC {ECO:0000256|ARBA:ARBA00007256}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL215525; KFV65041.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093IE63; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR CDD; cd22579; MPEG1_P2; 1.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR039707; MPEG1.
DR PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00023130};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..300
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV65041.1"
FT NON_TER 609
FT /evidence="ECO:0000313|EMBL:KFV65041.1"
SQ SEQUENCE 609 AA; 65993 MW; 0407C9739BB77A9C CRC64;
LPGGGWDNLR NLDMGRVFSL SYSLCKTTED GAYVIPDEIF TIPRKQSNLD INSEIIESWK
DYRSITSASI NLELSLYSFI NGKFSFDFHQ AKTHQVRDQA VTTRAQVRNL VYTAKIDPGA
ALDKGFKRQL LAIASHLESN QTRMADFLAE VLVLNYGTHA VTSVDAGATL VQEDQIKATF
LRDNWATRSA VTASAGVAFH SIISLKTEES LSASSGITKQ YLENRTHSRV ESIGGPLFYP
GITLKTWQEG IRNQLAALDR SGLPLYFFIT PSALPELPTP TVRRLARRVE TAARRYYAFN
TSPGCTDAAS PNFNFQANTD DGSCRGSAAN FTFGGAFQTC AGLAGPGAAA MCQGLAQRNP
ATGAFSCPSD YTPVLLGVQE REEGHSRLDC RSKCFLNWFC RRRCQDVFQL SRVRFSAYWC
AASRSVAPGS GYLFGGLFST RSANYVTGAQ SCPSGYFPLK LFDELQVCVS QDYEAGGPYA
VSFGGFFSCQ AGNPLVKHQG TTEDSYAKSC PPGFSQHLAL ISDSCLVQHC IPAGIFTAGS
LPPARLPPFT RPSPSLPDTD TVLVSSGDGA STWVRDGQSH AWRLAQPEEV QQAAEMLRGR
GPTGGEGAG
//
