ID A0A093ILY8_EURHL Unreviewed; 695 AA.
AC A0A093ILY8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Rho guanine nucleotide exchange factor 6 {ECO:0000313|EMBL:KFW03725.1};
DE Flags: Fragment;
GN ORFNames=N326_10216 {ECO:0000313|EMBL:KFW03725.1};
OS Eurypyga helias (Sunbittern) (Ardea helias).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Eurypygiformes;
OC Eurypygidae; Eurypyga.
OX NCBI_TaxID=54383 {ECO:0000313|EMBL:KFW03725.1, ECO:0000313|Proteomes:UP000054232};
RN [1] {ECO:0000313|EMBL:KFW03725.1, ECO:0000313|Proteomes:UP000054232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N326 {ECO:0000313|EMBL:KFW03725.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR EMBL; KK565018; KFW03725.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093ILY8; -.
DR Proteomes; UP000054232; Unassembled WGS sequence.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12060; SH3_alphaPIX; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035788; AlphaPIX_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000054232};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 80..139
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 161..341
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 363..468
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 30..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 300..362
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 637..678
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 30..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW03725.1"
FT NON_TER 695
FT /evidence="ECO:0000313|EMBL:KFW03725.1"
SQ SEQUENCE 695 AA; 78181 MW; EB71880C3AE1F953 CRC64;
LQVFDPHDLY TGEQFSKVLS TLTAVNKATE EQPSKGPCSH LSSLSSAAGG PHADSNSNAS
QSEKVSRRQS KPVEMTENGS HQLVVKARFN FKQTNEDELS VNKGDIIYVT RVEEGGWWEG
TLNGKTGWFP SNYVREIKST DKPLSPKALK GLESTQLTKN YYPVVLQNIL ETERDYAKEL
QSLLGTYLRP LQSYDKLSAV DIASLLGNVE EISAFQQTLN QALEEVAKLP ENQQRVGGCF
MSLMPQFRSL YLTYCANHPS AVSVLTQHSD ELEKFMESQG AANPGILILT TSLSKPFLRL
DKYVTLLQEL ERHMEEAHAD HEEVLKAVTS FKSLVSQCQE LRKRKQLELQ ILSETIQRWE
GEDIKTMGNI IYMSQVLVQC GGSEEKEERY FLLFSNVLLM LSASPRMSGF IYQGKLPLTG
MTLTKLEDAE GNEHMFEIAG NMMERITVSC STSQDLHEWL DHLQRLTKGT CNTISKTQSW
STHSVRTFSS AGQIRGPLEP PKILKPWSLS CLRPAPPLRP SAALSYKEVI IPPACRGPCK
SPKTMKKFLP KRKTERKPSD EEFVIRKSTA ALEEDAQILK VIEAYCTGAG FQQALSSGSR
KDSIPQVLLP EEEKIIVEET RSNGQTVTEE KSLVDTVYAL KDEVKELKQE NKRMKQCLEE
ELKSRKDLEK LVRRLLKQTD ECGREDTGRK SSLIA
//
