ID A0A093IMS7_FULGA Unreviewed; 837 AA.
AC A0A093IMS7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
DE Flags: Fragment;
GN ORFNames=N327_02302 {ECO:0000313|EMBL:KFW00039.1};
OS Fulmarus glacialis (Northern fulmar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae;
OC Fulmarus.
OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW00039.1, ECO:0000313|Proteomes:UP000053806};
RN [1] {ECO:0000313|EMBL:KFW00039.1, ECO:0000313|Proteomes:UP000053806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW00039.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome
CC membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004195}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK590894; KFW00039.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093IMS7; -.
DR Proteomes; UP000053806; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR018410; Na/H_exchanger_3/5.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF56; SODIUM_HYDROGEN EXCHANGER 5; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR PRINTS; PR01087; NAHEXCHNGR3.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053806};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT TRANSMEM 26..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..408
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 601..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW00039.1"
FT NON_TER 837
FT /evidence="ECO:0000313|EMBL:KFW00039.1"
SQ SEQUENCE 837 AA; 92902 MW; EA6BC4A37505B9E0 CRC64;
PCACLADALI LPFLLVFHLS RKVTSIVPES CLLILLGLGL GGIVLAVAKK AEFQLEPNMF
FLFLLPPIVL DSGYFMPSRL FFDNIGAILT YAVVGTLWNS FTTGAALWGL HRAGLMDPGV
EAGLMDFLLF GSLISAVDPV AVLAVFEEVH VNETLFIIVF GESLLNDAVT VVLYKVFNSF
VELGPAHIHA TDYVKGVASF FLVSLGGTAV GLLFAFLLAL ITRFTKRVRI IEPLFVFLLA
YVAYLAAEMV SLSSILAVTF CGICCKKYVE ANISQKSRTT VKYTMKTLAS SSETIIFMFL
GISAVDTSKW AWDTALVLGT LFFILLFRAV GVVLQTYVLN RFRLIPLDRI DQVVMSYGGL
RGAVAFALVI LLDRAKVKAK DYFVATTIVV VFFTVIVQGL TIKPLVTWLK VKRSDHHKPT
LNEELHEHAF DHILAAVEDI VGHHGYHYWR DKWEQFDKKY LSQLLMRKSA YRLRDEIWDV
YYKLNIRDAI SFVDQVGACD GGRAVGWPRQ ESAGLGWWRE SGSGACLDLQ VIDTVRSRRD
KEDAAMPAHP VSLCLSLGQY KASYSRHFIS PDKQERQDKE IFRQNMKRRL ETFKSTKHNV
CSSKSKARLK EKGRKKASAP QPPAPLLALR FALPQAADTP VLVMVSSEEE ESDSSETERE
DDEGIVFIAR ATDEVLQGKT TPGSLDVCPS PCIIPPSPTL AEKELPWKGD QADLAVYISS
ETTKIVPVDM QKAWNQSISS LESIASPPGI ESGPQHRRFA CPVLEEQPQS ASQAMPEQSS
CFQFPSHISK SGRSQSDSSP DGAEQQELQP LMATEEQGRE LPAAEPRWLM FNRASHL
//
