ID A0A093IP88_FULGA Unreviewed; 593 AA.
AC A0A093IP88;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Large subunit GTPase 1 homolog {ECO:0000256|ARBA:ARBA00040145};
DE Flags: Fragment;
GN ORFNames=N327_03775 {ECO:0000313|EMBL:KFW00549.1};
OS Fulmarus glacialis (Northern fulmar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae;
OC Fulmarus.
OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW00549.1, ECO:0000313|Proteomes:UP000053806};
RN [1] {ECO:0000313|EMBL:KFW00549.1, ECO:0000313|Proteomes:UP000053806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW00549.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase required for the XPO1/CRM1-mediated nuclear export of
CC the 60S ribosomal subunit. Probably acts by mediating the release of
CC NMD3 from the 60S ribosomal subunit after export into the cytoplasm.
CC {ECO:0000256|ARBA:ARBA00037461}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KK591640; KFW00549.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093IP88; -.
DR Proteomes; UP000053806; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd01857; HSR1_MMR1; 1.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR043358; GNL1-like.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45709:SF2; LARGE SUBUNIT GTPASE 1 HOMOLOG; 1.
DR PANTHER; PTHR45709; LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053806}.
FT DOMAIN 88..373
FT /note="CP-type G"
FT /evidence="ECO:0000259|PROSITE:PS51721"
FT REGION 177..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..207
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..249
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..593
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW00549.1"
FT NON_TER 593
FT /evidence="ECO:0000313|EMBL:KFW00549.1"
SQ SEQUENCE 593 AA; 67465 MW; F773321DA3E7870D CRC64;
RLNIQIVSAQ SRTGLLTAQE AQRVRQLHEE NQQFLRIPRR PQWDRTTSAE DLKQAERESF
LEWRRQLAHL EEEKKLILTP FERNLEFWRQ LWRVIERSDI VVQIVDARNP LLFRCQDLES
YVKEVSNDKE NMILINKADL LSEEQRAAWA QFFEKEGVKV VFWSALAECK RLSGEAKELD
TEDVAEDLSD SEDGSSSQED DDDTPQDSTE STSTGNALQT VNHVLVSDDD SSDEYEDCED
DEEEAWQTCS EDEGGDKVNA IAPERIESRT DGAAVQHVVQ EQNRNIRNFS HLVQRNELLE
IFKTMHNGPR VKDGEVNVGL VGYPNVGKSS TINTILRNKK VSVSATPGRT KHFQTLYVEP
GLCLCDCPGL VMPSFISTKA EMICSGILPI DQMRDHVPPI SLISFAWAYI CQHIPRNVLE
ATYGINIIRP REDEDPDRKP TAEELLTAYG YMRGFMTAHG QPDQPRSARY VLKDYVSGKL
LYCHPPPGID PNGFQHQHQI CPQSRTVQAS GQVKPEKNTK AKQIENVVDK TFFHQENVRA
LMKGVRAAMG YRPGSGLVPV TTPNSGNVVG KPWKKHGNRN KKEKIRRITK HLE
//
