ID A0A093IQ79_FULGA Unreviewed; 1259 AA.
AC A0A093IQ79;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Niemann-Pick C1 protein {ECO:0000313|EMBL:KFW01787.1};
DE Flags: Fragment;
GN ORFNames=N327_03510 {ECO:0000313|EMBL:KFW01787.1};
OS Fulmarus glacialis (Northern fulmar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae;
OC Fulmarus.
OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW01787.1, ECO:0000313|Proteomes:UP000053806};
RN [1] {ECO:0000313|EMBL:KFW01787.1, ECO:0000313|Proteomes:UP000053806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW01787.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KK593676; KFW01787.1; -; Genomic_DNA.
DR RefSeq; XP_009572601.1; XM_009574306.1.
DR AlphaFoldDB; A0A093IQ79; -.
DR GeneID; 104074245; -.
DR KEGG; fga:104074245; -.
DR CTD; 4864; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000053806; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053806};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 241..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1079..1098
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1105..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1171..1197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1209..1232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 602..767
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW01787.1"
FT NON_TER 1259
FT /evidence="ECO:0000313|EMBL:KFW01787.1"
SQ SEQUENCE 1259 AA; 140759 MW; C6961CCB5C9E7468 CRC64;
VLPQLCVWYG ECGVASGDKR YNCAYDGPPI ALPEDGYDLM QELCPGLFFG SVSTCCDVRQ
LQTLKNNLQL PLQFLSRCPS CFYNLINLFC ELTCSPNQSD FLNVTSTIPY YDPILKENKS
SITELQYFIG ERFANAMYNA CKDVEAPSSN VKALGLLCGK DVKDCNATNW IEYMFSKDNG
QTPFSIIPIF SDVPVHGMNP MNNATKGCNE SMDDSTGPCS CQDCSIVCGP KPQPPPLPAP
WLLFGLDAVY VIMWISYMGF LLIFFALVFG VWCYRRRHFV SEYTPIDSNI AFSVNSHRDN
GKINCGERLG ERFENGLRMT FTSWGAFCVR NPRPVILFSV VFIAMCCSGF VYVKATTNPV
DLWSAPSSQA RKEKEYFDTH FGPFFRTEQL IIQAPNSHPD TYSPYPSGAD VPFGPPLGKE
ILHQVLDLQD AIVNITASFD NETVMLKDIC LAPLTPYNNN CTILSVLNYF QNSHSVLDHT
IGDEFFVYAD YHSHFLYCVR APASLNDTSL LHDPCLGTFG GPVFPWLVLG GYDDDNYNNA
TALVITFPVN NYYNDSRKLM KALAWEKEFI NFLKNYNNPN LTISFSAERS IEDEINRESK
SDIGTVLISY IVMFVYISLA LGRIQSCRRL LVDSKISMGI AGILIVLSSV ACSVGIFSYF
GIPLTLIVIE VIPFLVLAIG VDNIFIIVQT LQRDERLQGE TLDKQIGRVL GDVAPSMFLS
SFSETVAFFL GTLSTMPAVR TFSLFAGMAV LIDFILQVTC FVSLLGLDIR RQERNRLDIL
CCIKGNEEMS GVQRSESILF QFFKNLYSPY LLKDWMRPIV IAVFVGVLSF STAVMHNVEI
GLDQSLSMPD DSYVMDYFSQ LSKYLHAGPP VYFVLEEGHN YTSLEGQNMV CGGMGCNNDS
LVQQVFNAAE IGSYTRIGYA PSSWIDDYFD WVKPQSSCCR VYNTTGQFCN ASVTDPSCTR
CRPLTQEGKQ RPQGKDFMTF LPMFLSDNPN PKCGKGGHAA YNSAVNFINN KSDIGATYFM
TYHTVLKTSS DFIDAMKKAR VIADNITETM GIKEKNYRVF PYSVFYVFYE QYLTIVHDAI
FNLCISLGSI FLVTTVLLGF EVWAAVVVAV TIAMIIVNMF GVMWLWGISL NAVSLVNLVM
SCGIAVEFCS HVTRAFTVST KGSRVERAEE ALSHMGSSVF SGITLTKFGG IVVLAFSKSQ
IFKIFYFRMY LAMVLLGATH GLIFLPVLLS YIGPSVNKAK TRAAQERTRG TERERLLYF
//
