ID A0A093ITK7_DRYPU Unreviewed; 256 AA.
AC A0A093ITK7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Pro-thyrotropin-releasing hormone {ECO:0000256|PIRNR:PIRNR001795};
GN ORFNames=N307_02270 {ECO:0000313|EMBL:KFV70051.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV70051.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV70051.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV70051.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems.
CC {ECO:0000256|PIRNR:PIRNR001795}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000256|ARBA:ARBA00010437,
CC ECO:0000256|PIRNR:PIRNR001795}.
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DR EMBL; KL216544; KFV70051.1; -; Genomic_DNA.
DR RefSeq; XP_009902353.1; XM_009904051.1.
DR AlphaFoldDB; A0A093ITK7; -.
DR STRING; 118200.A0A093ITK7; -.
DR GeneID; 104303432; -.
DR KEGG; dpub:104303432; -.
DR CTD; 7200; -.
DR OrthoDB; 5356148at2759; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR InterPro; IPR008857; TRH.
DR PANTHER; PTHR17530; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR PANTHER; PTHR17530:SF2; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|PIRNR:PIRNR001795};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001795};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR001795}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT CHAIN 24..256
FT /note="Pro-thyrotropin-releasing hormone"
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT /id="PRO_5010009593"
FT REGION 84..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 29202 MW; 5370877048F48B66 CRC64;
MPSIQLPLLL LCLTLSGVCL NGGQPLPEES ENMVKPPLGD ILQRSESRLK SALKNAEEMN
KEPNALLPEW LSKRQHSGKK YLSDLVKRQH PGKRDAEEDT SYGDAQKRQY PGKGETQDDL
DSYLELKKRQ HPGRRWLSDQ DADTPAAQPT YFNQLPKRQH PGKRYLMSKW QHPSRRGWND
EVEVNKQYGE ERQHAGKSPW NSDSPEDAGP CSFQEPFTCS KGSLLLHLVE SVSKDRGEEK
HQHPGKRSAR ESETEE
//
