ID A0A093IU83_EURHL Unreviewed; 652 AA.
AC A0A093IU83;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=[heparan sulfate]-glucosamine N-sulfotransferase {ECO:0000256|ARBA:ARBA00012979};
DE EC=2.8.2.8 {ECO:0000256|ARBA:ARBA00012979};
GN ORFNames=N326_02494 {ECO:0000313|EMBL:KFW06290.1};
OS Eurypyga helias (Sunbittern) (Ardea helias).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Eurypygimorphae; Eurypygiformes;
OC Eurypygidae; Eurypyga.
OX NCBI_TaxID=54383 {ECO:0000313|EMBL:KFW06290.1, ECO:0000313|Proteomes:UP000054232};
RN [1] {ECO:0000313|EMBL:KFW06290.1, ECO:0000313|Proteomes:UP000054232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N326 {ECO:0000313|EMBL:KFW06290.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC {ECO:0000256|ARBA:ARBA00010420}.
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DR EMBL; KK569165; KFW06290.1; -; Genomic_DNA.
DR RefSeq; XP_010151002.1; XM_010152700.1.
DR AlphaFoldDB; A0A093IU83; -.
DR GeneID; 104510451; -.
DR KEGG; ehs:104510451; -.
DR CTD; 8509; -.
DR OrthoDB; 2913264at2759; -.
DR UniPathway; UPA00756; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000054232; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0019213; F:deacetylase activity; IEA:UniProt.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF53; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 2; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054232};
KW Transferase {ECO:0000313|EMBL:KFW06290.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..510
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT DOMAIN 600..652
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 609
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
SQ SEQUENCE 652 AA; 75016 MW; B3F48BAE997084B6 CRC64;
MIQLWKVVRH VRQLELHRLI LVLIGFSLIS MCILAYYVTN SPKIKEPPPL PFSDCSNQHR
ILIPPQASWR LTKSVDTSRT DPVVLVFVES IYSQLGQEIV AILESSRFKY RTEIAPGKGD
MPTLTDKDRG RYALIIYENI LKYVNLDAWN RELLDKYCVE YGVGIIGFFK ANENSLLSAQ
LKGFPLFLHS NLGLRDYHIN PSAPLLYVTR ANEVEQGPLP GDDWTVFQSN HSTYEPVLLA
STKSSESIPH LATHKALHAT VVQDLGLHDG IQRVLFGNNL NFWLHKLIFV DAIAYLTGKR
LCLTLDRYIL VDIDDIFVGK EGTRMKVSDV EALLSTQNKL RTLVPNFTFN LGFSGKFYHT
GTDEEDEGDD MLLKHRKEFW WFPHMWSHMQ PHLFHNVTVL AEQMKLNKQF AVEHGIPTDL
GYAVAPHHSG VYPVHTQLYE AWKSVWSIQV TSTEEYPHLR PARYRHGFIH NGIMVLPRQT
CGLFTHTIFY NEYPGGSKEL DKSIRGGELF LTVLLNPISI FMTHLSNYGN DRLGLYTFES
LVKFVQCWTN LRLQTLPPVQ LAKKYFEIFP QEKNPLWQNP CDDKRHKDIW SKEKTCDRLP
KFLIVGPQKT GTTAVHFFLT MHPAVTSNFP SPSTFEEIQF FNGPNYHKGI DW
//
