ID A0A093J0S2_FULGA Unreviewed; 546 AA.
AC A0A093J0S2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Poly(A)-specific ribonuclease PARN {ECO:0000256|ARBA:ARBA00015918};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
DE AltName: Full=Polyadenylate-specific ribonuclease {ECO:0000256|ARBA:ARBA00031923};
DE Flags: Fragment;
GN ORFNames=N327_00672 {ECO:0000313|EMBL:KFW04594.1};
OS Fulmarus glacialis (Northern fulmar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Procellariiformes; Procellariidae;
OC Fulmarus.
OX NCBI_TaxID=30455 {ECO:0000313|EMBL:KFW04594.1, ECO:0000313|Proteomes:UP000053806};
RN [1] {ECO:0000313|EMBL:KFW04594.1, ECO:0000313|Proteomes:UP000053806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N327 {ECO:0000313|EMBL:KFW04594.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001663};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR EMBL; KK598280; KFW04594.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093J0S2; -.
DR Proteomes; UP000053806; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR CDD; cd02637; R3H_PARN; 1.
DR CDD; cd12428; RRM_PARN; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034042; PARN_R3H.
DR InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF44; POLY(A)-SPECIFIC RIBONUCLEASE PARN; 1.
DR Pfam; PF04857; CAF1; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF08675; RNA_bind; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS51061; R3H; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000053806}.
FT DOMAIN 175..242
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW04594.1"
FT NON_TER 546
FT /evidence="ECO:0000313|EMBL:KFW04594.1"
SQ SEQUENCE 546 AA; 63243 MW; F8ED5674858B9757 CRC64;
LPADFKDNLN KVYEAIEESD FLAIDGEFSG ISDGPSVSAL TNGFDTPEER YQKLKKHSMD
FLLFQFGLCT FKYDHTEEKY IMKSFNFYIF PKPFNRSSPD VKFVCQSSSI DFLANQGFDF
NKVFRNGIPY LNQEEERQLR EQYDEKRSQA NGAGSLSYIS PNATKCPVTI PEDQKKFIEK
VVEQIEDLLK NEENESLELE PCTGFQRKLI YQTLSWKYPK GIHVETLESD KKERYIVISK
VNEEERKRRE QQKQAKEQEE LNDAVGFSRV VHAIANSGKL VIGHNMLLDV MHTIHQFYCP
LPDDLSEFKE VTSCVFPRLL DTKLMASTQP FKEIINNTSL AELEKRLKEV PFSPPKVESA
EGFPSYDTAS EQLHEAGYDA YITGLCFISM ANFLGSFLSP PKNHVSARSK LIEPFFNKLF
LMRVMDIPYL NLEGPDLQPK RDHVLHVTFP KEWKTSDLYQ LFSAFGNIQV SWIDDTSAFV
SLSQPEQVQI AVNTSRYAES YRIQTYAEYV EKKHEEKQAK RKCTEDSWKE MERKRLKTQC
TPYVSQ
//
