ID   A0A093J322_EURHL        Unreviewed;       348 AA.
AC   A0A093J322;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=N-acylneuraminate cytidylyltransferase {ECO:0000256|ARBA:ARBA00012491};
DE            EC=2.7.7.43 {ECO:0000256|ARBA:ARBA00012491};
DE   Flags: Fragment;
GN   ORFNames=N326_01880 {ECO:0000313|EMBL:KFW06297.1};
OS   Eurypyga helias (Sunbittern) (Ardea helias).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Eurypygimorphae; Eurypygiformes;
OC   Eurypygidae; Eurypyga.
OX   NCBI_TaxID=54383 {ECO:0000313|EMBL:KFW06297.1, ECO:0000313|Proteomes:UP000054232};
RN   [1] {ECO:0000313|EMBL:KFW06297.1, ECO:0000313|Proteomes:UP000054232}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N326 {ECO:0000313|EMBL:KFW06297.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC         diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC         Evidence={ECO:0000256|ARBA:ARBA00001862};
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005141}.
CC   -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family.
CC       {ECO:0000256|ARBA:ARBA00010726}.
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DR   EMBL; KK569175; KFW06297.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093J322; -.
DR   UniPathway; UPA00628; -.
DR   Proteomes; UP000054232; Unassembled WGS sequence.
DR   GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR003329; Cytidylyl_trans.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR   PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR   Pfam; PF02348; CTP_transf_3; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:KFW06297.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054232};
KW   Transferase {ECO:0000313|EMBL:KFW06297.1}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW06297.1"
FT   NON_TER         348
FT                   /evidence="ECO:0000313|EMBL:KFW06297.1"
SQ   SEQUENCE   348 AA;  39479 MW;  C93530673713FD5F CRC64;
     NSIWVSTDHD EIEKVAKQFG AQVHRRSPEV SQDSSTSLEA IREFLNHHHE VDIVGNIQAT
     SPCLHPSDLV KVADLIQKEG FDSVFSVVRR HQFRWSEVKK GENKMTEPQN LNPAKRYRRQ
     DWPGELYENG SFYFAKRHLI EKGYLQGGKM AYYEMRAEHS VDIDIDIDWP IAEQRVLSFG
     YFGKEPLKEV KLLVCSVDGC LTNGRIYVTE DQKEMVSYDY RDIVGIDLLK KRGIQVRFLS
     ERDCSKTLSA MQLGCVAKVS VTNKLQVLED WQEDMGLSWK EVAYLGNEES DVECLKKAGM
     SAVPADACAL AQKAAGYICK SSGGCGAVRE FAEHIFLLLE KVNSSRKQ
//