ID A0A093JC95_STRCA Unreviewed; 309 AA.
AC A0A093JC95;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Mitochondrial thiamine pyrophosphate carrier {ECO:0000256|ARBA:ARBA00040836};
DE AltName: Full=Solute carrier family 25 member 19 {ECO:0000256|ARBA:ARBA00041879};
DE Flags: Fragment;
GN ORFNames=N308_09441 {ECO:0000313|EMBL:KFV76534.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV76534.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV76534.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV76534.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial transporter mediating uptake of thiamine
CC diphosphate into mitochondria. It is not clear if the antiporter
CC activity is affected by the membrane potential or by the proton
CC electrochemical gradient. {ECO:0000256|ARBA:ARBA00037549}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=thiamine diphosphate(in) + thiamine phosphate(out) = thiamine
CC diphosphate(out) + thiamine phosphate(in); Xref=Rhea:RHEA:73383,
CC ChEBI:CHEBI:37575, ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00035968};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL205911; KFV76534.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093JC95; -.
DR STRING; 441894.ENSSCUP00000002662; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090422; F:thiamine pyrophosphate transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR24089:SF59; MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER; 1.
DR PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 11..104
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 114..200
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 212..307
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT NON_TER 309
FT /evidence="ECO:0000313|EMBL:KFV76534.1"
SQ SEQUENCE 309 AA; 34030 MW; 1CB52C1C95BD5D59 CRC64;
MVGYDPEAKC VSTLEAAAAG SAAGLVNRVL VSPLDVIKIR FQLQIEQLSS RNPLAKYHGI
LQAAQRIFRE EGLVAFWKGH VPAQFLSVGF GAVQFMVFES LTKLVHNVTS YSARDSFVHF
VCGGLAACTA TAAAQPVDTL RTRFAAQGEP KIYHSLRHAV VTMYQTEGPL TFYRGLTPTI
VAVFPYAGLQ FSFYNILQQF SEWVIPAEGK KAGNVKNLVC GSCAGIISKT LTYPFDLFKK
RLQVCGFEHA RLAFGQVRIY RGLLDCVRQI MREEGPGGFF KGLSPSLLKA AVSTGLIFFW
YELFCSLLC
//
