ID A0A093JEY1_DRYPU Unreviewed; 2193 AA.
AC A0A093JEY1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 28-JUN-2023, entry version 25.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|RuleBase:RU364134};
DE Flags: Fragment;
GN ORFNames=N307_01009 {ECO:0000313|EMBL:KFV77399.1};
OS Dryobates pubescens (Downy woodpecker) (Picoides pubescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Piciformes; Picidae; Dryobates.
OX NCBI_TaxID=118200 {ECO:0000313|EMBL:KFV77399.1, ECO:0000313|Proteomes:UP000053875};
RN [1] {ECO:0000313|EMBL:KFV77399.1, ECO:0000313|Proteomes:UP000053875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N307 {ECO:0000313|EMBL:KFV77399.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL217402; KFV77399.1; -; Genomic_DNA.
DR STRING; 118200.A0A093JEY1; -.
DR Proteomes; UP000053875; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF1; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13-LIKE; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000053875};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1393..1744
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1780..2182
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 411..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1505..1526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1542..1640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2029..2061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1071
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1542..1634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV77399.1"
FT NON_TER 2193
FT /evidence="ECO:0000313|EMBL:KFV77399.1"
SQ SEQUENCE 2193 AA; 240830 MW; 16213AAFE68ADC85 CRC64;
AELTGIKWRR YNFEGHGDCG PIISAPAQDD PILLSFIRCL QANLLCVWRR DVKPDCKELW
IFWWGDEPNL VDVIHRELHM VEEGLWENGL SYECRTLLFK AIHNLLERCL MDKNFVRIGK
WFIRPYDKDE KPVNKSEHLS CAFTFFLHGE SNVCTSVEIA QHQPIYLINE EHIQMAQSSP
SPFQVLVSPY GLNGTLTGQS YKMSDPATRK LMEEWQYFYP MVLKKKEGIK EEEELGYDND
FPVAVEVIVG GVRMVYPSAF VLISQSDIPM SQNAASTGGH INVGQQGLGS VKDPASTCGM
PLTPPTSPEQ ALMGESGCSQ SSVSHSAVQE GTVSVHSPKK SGKIAPKFHN HMVHRVWKEC
ILNRSQSKRN QITTANLEEE VPNNTVSWDF VDPVQRVSCS CSRHKVFKQR CAAGSSRPPT
INQPGFSVGT SSSSALPPPA SSKHKTTERQ EKGDKLQKRP LMPFHHRPSV TEELCMEQDT
SGQKLGLAGM EPSLEVPSSR KYEKPLSIPA RNPSKQMNMN PMDSPHSPTS PLPPTLSPQP
RGQEAENLDP PAVPVNPALY GSGLELQPLP SLDDRTVLVG QRLPLMAEVS ETALYCGVIQ
NNESLDMWRT YSVPSSDNLE FRPPDLPCER YDAKMEVSSD STALKRLLAQ PNKRFKILEE
QKPVQTLNYL DPLPLLQQPG EGLGDASDPY TFEDGDIKYS FTGNKKCKLG AEKDPLKKSK
SEDGIGTKEI PPTGHSTPVP EGKDAMSIFS SAPKADTRQD NAAGRAGSGS LTQVTDLAPS
LHDLDNIFDN SDEDELGAVS PALRSSKLPA AGSEERPLGK DGRTTVPYPP TVADLQRMFP
TPPSLEQHPA FSPVMSYKDG ISSETVTTLG MMESPMVNMV PTQLAEFKME VEDGLGSPKP
EELKDFSYVH KVPSFQPFVG SSVFAPLKIL PSQCLLPLKI PDACIFRPSW AVPPKIEQLP
LPPAATFIRD GYNNVPSVGS LADQDYLQMN TPQMNTPVTL NSTAPASNSG AGVLPSPATP
RFSVPTPRTP RTPRTPRGGG TASGQGSVKY DSTDQGSPAS TPSTTRPLNS VEPATVQPIP
EAHSLYVTLI LSDSVLNIFK DRNFDSCCIC ACNMNIKGAD VGLYIPDSSN EDQYRCTCGF
SAIMNRKLGY NSGLFIEDEL DIFGKTSDIG QAAERRLMVC QSNLISQMGE GARRTQEPPM
SLLLLLQNQH TQPFTSLSCL DYMASNNRQT LPCMNWSYDR LQADSNDSWV ECFNALEQGR
QYVDNPTGGK VDEALVRSAT VHSWPHSNVL DISMLSSQDV VRMLLSLQPF LQDAIQKKRT
GRTWENIQHV QGPLTWQQFH KMAGRGTYGS EESPEPLPIP TLLVGYDKDF LTISPFSLPF
WERLLLDPYG GHRDVAYIVV CPENEALLDG AKTFFRDLSA VYEMCRLGQH KPICKVLRDG
IMRVGKSVAQ KLTDELVSEW FSQPWGSEEC DNHSRLKLYA QVCRHHLAPY LATLQLDSSL
LLPPKYQTPP PASQTQTAPG NTGPVASNSA CLSAAGAAPT GNSFNSTPGG GTSSLPAGSS
SSSGSSVPQL SASSATPGVN QMAATSTPGF SGNIGSGQNT STGANTAERS QGSTAPGGDA
ESGQNLPQQP QEGQEGVTER ERIGIPTEPE SADSNAYPPA VVIYMVDPFT YTADEESAST
NFWLLSLMRC YTEMLDNLPE NMRNSFILQI VPCQYMLQTM KDEQVFYIQH LKSLAFSVYC
QCRRPLPTQI HIKSLTGFGP AASIEMTLKN PERPSPIQLY SPPFILAPIK DKQTELGETF
GEASQKYNVL FVGYCLSHDQ RWLLASCTDL HGELLETCIV NIDLPNRSRR SKLSARKIGL
QKLWEWCIGI VQMTSLPWRV VIGRLGRLGH GELKDWSILL GECSLQTISK QLKEVCRMCG
ISAADSPSIL SACLVAMEPQ GSFVVMPDAV TMGSVFGRST ALNLQSSQLN TPQDASCTHI
LVFPTSATIQ VAPANYPNED GFSPTNDDMF DLPFPDDMDN DIRILITGNL HSSPNSSPVP
SPGSPSGIGV GSHYQHSRNQ GERLLSREAP EELKQQPLAL GYFVSTAKAE NLPQWFWSSC
PQAQNQCPLF LKASLHHHIS VAQTDELLPA RNSQRVPHPL DSKTTSDVLR FVLEQYNALS
WLTCNPATQD RSSCLPVHFV VLTQLYNAIM NIL
//
