ID A0A093JQ16_STRCA Unreviewed; 544 AA.
AC A0A093JQ16;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Neuroendocrine convertase 2 {ECO:0000313|EMBL:KFV80769.1};
DE Flags: Fragment;
GN ORFNames=N308_11881 {ECO:0000313|EMBL:KFV80769.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV80769.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV80769.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV80769.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
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DR EMBL; KL206273; KFV80769.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093JQ16; -.
DR STRING; 441894.ENSSCUP00000015099; -.
DR MEROPS; S08.073; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016486; P:peptide hormone processing; IEA:UniProt.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF13; NEUROENDOCRINE CONVERTASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 368..504
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 74
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 115
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 291
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV80769.1"
FT NON_TER 544
FT /evidence="ECO:0000313|EMBL:KFV80769.1"
SQ SEQUENCE 544 AA; 59915 MW; 8EAA33E1DEB19AF2 CRC64;
QVKKAVQQEG FSRRKRGYRD INDIDINMND PLFTKQWYLI NTGQADGTPG LDLNVAEAWE
LGYTGKGVTI GIMDDGIDYL HPDLASNYNA KASYDFSSND PYPYPRYTDD WFNSHGTRCA
GEVSAAANNN ICGVGVAYNS KVAGIRMLDQ PFMTDIIEAS SISHMPQVID IYSASWGPTD
NGKTVDGPRE LTLQAMADGV NKGRGGKGSI YVWASGDGGS YDDCNCDGYA SSMWTISINS
AINDGRTALY DESCSSTLAS TFSNGRKRNP EAGVATTDLY GNCTLRHSGT SAAAPEAAGV
FALALEANLD LTWRDMQHLT VLTSKRNQLH DEVHQWRRNG VGLEFNHLFG YGVLDAGAMV
KMAKDWKTVP ERFHCVGGSI QEPEKIPSSG KLVLTLTTDA CEGKENFVRY LEHVQAVITV
NSTRRGDLNI NMTSPMGTKS ILLSRRPRDD DSKVGFDKWP FMTTHTWGED PRGTWALEIG
FVGGVPQRGV LKEWTLMLHG TQSAPYIDQI VKDYQSKLAM SKKEELEEEL DEAVERSLKS
ILSK
//
