ID A0A093N8Z6_PYGAD Unreviewed; 770 AA.
AC A0A093N8Z6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Carnitine O-palmitoyltransferase 1, liver isoform {ECO:0000313|EMBL:KFW61478.1};
GN ORFNames=AS28_11008 {ECO:0000313|EMBL:KFW61478.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW61478.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW61478.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW61478.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR EMBL; KL224602; KFW61478.1; -; Genomic_DNA.
DR RefSeq; XP_009325609.1; XM_009327334.1.
DR AlphaFoldDB; A0A093N8Z6; -.
DR STRING; 9238.A0A093N8Z6; -.
DR GeneID; 103919774; -.
DR KEGG; padl:103919774; -.
DR CTD; 1374; -.
DR OrthoDB; 1429709at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF74; CARNITINE O-PALMITOYLTRANSFERASE 1, LIVER ISOFORM; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..47
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 174..753
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 473
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 770 AA; 87960 MW; 48111A93D2B924BA CRC64;
MAEAHQAVAF QFTVTPDGID LRMSHEALKQ IYLSGVHSWK KKFIRFKNGI ITGVYPASPS
SWLIVVVGVM STMYAKIDPS LGIIAKINRT LDTTGYMSNQ TQNIVSGILF GTGLWVALIV
TMRYSLKMLL SYHGWMFAEH GKLSAGTKFW MALVKLFSGR KPMLYSFQTS LPRLPVPAVK
DTVNRYLESV QPLMDDEEFR RMEGLAKDFA FNLGPRLQWY LKLKSWWATN YVSDWWEEYI
YLRGRGPIMV NSNYFAMDFL YLSPTTLQAA RAGNVIHAIL LYRKKLDRQE IKPILLMGST
VPLCSAQWER MFNTSRIPGE ESDTLQHVKD SKHIVVYHKG RYFKVWLYHD GRLLKPREIE
QQMQRILDDD SEPQAGEEKL AALTAGDRVP WAKARQTYFS HGKNKQSLDA IEKAAFFVTL
DDIEQGYRKE DPVRSLDTYA KSLIHGRCYD RWFDKTFTLI IFKNGRTGLN AEHSWADAPI
VGHLWENAMA TEYLELGYSE DGHCKGDTNQ NIPIPTKLQW EIPEECQEVI ERSLSTAIAL
ADDVDFHSFF FDAFGKGLIK KAKTSPDAFV QLALQLAHYR DMGKFSLTYE ASMTRLFREG
RTETVRSCTV ESCNFVRTME DPAENNENKL KLFRLAAAKH QHLYRLAMTG AGIDRHLFCL
YVVSKYLAVD SPFLKEVLSE PWRLSTSQTP QQHIDLKKNP EMLSCGGGFG PVADDGYGVS
YIILDENSIH FHVSSKISCS ETDSHRFGKN IQKAMIDIMG LFNLSKNCTK
//
