ID A0A093NBT8_PYGAD Unreviewed; 375 AA.
AC A0A093NBT8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Signal transducer and transcription activator 6 {ECO:0000313|EMBL:KFW62413.1};
DE Flags: Fragment;
GN ORFNames=AS28_12402 {ECO:0000313|EMBL:KFW62413.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW62413.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW62413.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW62413.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL224636; KFW62413.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093NBT8; -.
DR STRING; 9238.A0A093NBT8; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16850; STAT6_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF48; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 255..365
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW62413.1"
FT NON_TER 375
FT /evidence="ECO:0000313|EMBL:KFW62413.1"
SQ SEQUENCE 375 AA; 42127 MW; A2C7B132213C6121 CRC64;
EVLSSLVKSS FLVEKQPPQV LKTQTKFQAS VRFLLGPQLL KASAKPYMVR ADMVTEKQAR
ELALSAYSNT LSESTGEIMH NVVALETNPT SGTCCANFKN VLLKKIKRCE RKGSESVTEE
KCAVLFSTTV AVTPSNLSIH LQVLSLPIVV IVHGNQDNNA KATVLWDNAF SEIDRVPFVV
AERVPWEKMC DTLNLKFMAE VQTTKGLLKE HYFFLAQKIF NDHSASLEDF QSRSVSWAQF
NKEILPGRGF TFWQWFDGVL DLTKRCLKSY WSDRLIIGFI SKQYVCKLLS TEPDGTFLLR
FSDSEIGGVT IAHVIRGKDG SSQVENIQPF SAKDLSIRSL GDRIRDLGQL RNLYPNTPKD
QAFGSHYNSE WVGAD
//
