ID A0A093NDC2_PYGAD Unreviewed; 768 AA.
AC A0A093NDC2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
DE Flags: Fragment;
GN ORFNames=AS28_00888 {ECO:0000313|EMBL:KFW62928.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW62928.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW62928.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW62928.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR EMBL; KL224723; KFW62928.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093NDC2; -.
DR STRING; 9238.A0A093NDC2; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF25; INTEGRIN BETA-3; 1.
DR Pfam; PF07974; EGF_2; 2.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 698..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..56
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 18..440
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 613..697
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 721..767
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT REGION 72..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 19..29
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 22..55
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 32..44
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 182..189
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 237..278
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 379..391
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 411..660
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 438..442
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 453..465
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 462..500
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 467..476
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 478..491
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 506..511
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 508..541
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 513..526
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 528..533
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 547..552
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 549..580
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 554..563
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 565..572
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 586..591
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 588..636
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 593..603
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 606..609
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 613..622
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 619..692
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 640..668
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW62928.1"
FT NON_TER 768
FT /evidence="ECO:0000313|EMBL:KFW62928.1"
SQ SEQUENCE 768 AA; 84766 MW; DCB59B2AC57F3C96 CRC64;
LCFAVSGGNI CTTRGVNSCK QCLAVSPLCA WCSAEDLPQS SPRCDLRTSL LQNGCGQEYI
EFPTSTVTIL EDRPLSNKGS GSSTTTQMSP QKIQLNLRPD DSQIFRVQVR QVEDYPVDIY
YLMDLSNSMK DDLRNIQNLG TKLASEMRKL TSNLRIGFGA FVDKPISPYM YISPPQAITN
PCYEIGETCL PMFGYKHVLS LTDEVTRFNE EVRKQSVSRN RDAPEGGFDA IIQATVCDEK
IGWRNDASHL LVFTTDAKTH IALDGRLAGI VQPNDAQCHI DKDNFYSAST TLDYPSLGLM
TEKLSQKNIN LIFAVTDTVV GLYQNYSELI PGTTVGTLSR DSSNVLQLIV DSYGKIRSKV
ELEVRDLPEE LSLAFNATCL NDEVIPGLKS CMGLKIGDTV SFSIEAKVRG CPRERQKSFT
IKPVGFKDSL TVVVNFNCDC SCESQAEANS SSCSRGNGTL ECGVCRCNPG RLGSHCECSE
EEYNPSQQDN CSPQPGQPLC SQRGECICRQ CVCHSSDFGK VTGKYCECDD FSCVRFKGQM
CSGHGQCNCG DCLCDSDWTG DYCNCTTRTD TCMSSNGLVC SGHGSCVCGK CDCTQPGSYG
DTCEKCPTCP DACTIKKDCV ECKKFERGVL MEQQSCSRMC RDEIETVQEL GDRGKDAVNC
TYKDEDDCVV RFQYYEDSSG KSILYVIEEP DCPKGPDVLV VLLSVTGAIL LIGLAALLIW
KLLITIHDRR EFARFEEEKA RAKWDTGHNP LYKEATSTFT NITYRGNM
//
