ID A0A093NNJ9_PYGAD Unreviewed; 2187 AA.
AC A0A093NNJ9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Unconventional myosin-VIIa {ECO:0000313|EMBL:KFW65686.1};
DE Flags: Fragment;
GN ORFNames=AS28_06371 {ECO:0000313|EMBL:KFW65686.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW65686.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW65686.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW65686.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KL224923; KFW65686.1; -; Genomic_DNA.
DR STRING; 9238.A0A093NNJ9; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF34; MYOSIN VIIA; 1.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 63..739
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1015..1251
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1256..1565
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1563..1632
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1707..1877
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1883..2187
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2112..2139
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 616..638
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 865..933
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 156..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW65686.1"
FT NON_TER 2187
FT /evidence="ECO:0000313|EMBL:KFW65686.1"
SQ SEQUENCE 2187 AA; 252061 MW; 6ABA7D85947555D8 CRC64;
LWFQGDYVWM DLKTGREFDV PIGAVVKLCD SGQIQVVDDE GNEHWISPQN ASHIKPMHPT
SIHGVEDMIR LGDLNEAGIL RNLLIRYREH LIYTYTGSIL VAVNPYQLLP IYSPEQIRLY
TNKKIGEMPP HIFAIADNCY FNMQRNNKDQ CCIISGESGA GKTESTKLIL QFLAAISGQH
SWIEQQVLEA NPILEAFGNA KTIRNDNSSR FGKYIDIHFN KRGAIEGAKI EQYLLEKSRV
CRQAQDERNY HVFYCMLRGM TMEQKKKLGL GKATDYNYLA MGNCTTCDGR DDSKEYANIR
SAMKVLMFTD TENWEISKLL AAILHMGNLQ YEARTYDNLD ACEVVQSASL ITAASLLEVD
PQDVMNCLTS RTIITRGETV STPLSMEQAL DVRDAFVKGI YGRLFVWIVE KINAAIYRPP
SQELKSVRRS IGLLDIFGFE NFTVNSFEQL CINFANENLQ QFFVRHVFKL EQEEYNLENI
NWQHIEFTDN QDALDMIAIK PMNIISLIDE ESKFPKGTDA TMLHKLNSQH KLNTNYIPPK
NNYETQFGIN HFAGIVYYET KGFLEKNRDT LHGDIIQLVH SSKNKFIKQI FQADVAMGAE
TRKRSPTLSS QFKRSLELLM RTLSVCQPFF VRCIKPNEYK KPMLFDRELC VRQLRYSGMM
ETIRIRRAGY PIRYTFVEFV DRYRVLMPGV KPAYKQGDLR GTCQRIAEAV LGKDDDWQIG
KTKIFLKDHH DMLLEIERDK AITDKVILIQ KVVRGFKDRS NFLKVRNSVL MIQRYWRGHN
CRKNYSAMRI GFLRLQALYR SRKLHKQYHM ARRRIIEFQA QCRGYLVRRA FRHRLWAVLT
IQAYARGMIA RRLYKRLRGE YHRRLEAEKL RLAEEERLRK EMSAKKAKEE AEKKHQVRLA
QLAREDAERE VKEKEEARRK KELLEKMEKA RNEPVNDSEM VDKMFGFLGT TSSLPGQEGQ
APNGFEDLER AQKELEEEDL DAALPLPEEE EEDLSEYKFA KFAATYFQGT TTHTYIRRPL
KQPLLYHEDE GDQLAALAVW ITILRFMGDL PEPKYHTAMS DGGEKIPVMT KIYETLGKKT
YKKELQALQG EGESTHIDGH KKNSVRHKLV SLTLKKKSKL TEEVTKRLHD GESTLQGNSM
LEDRPTSNLE KLHFIIGNGI LRPALRDEIY CQICKQLTQN PSKSSHARGW ILMSLCVGCF
APSEKFVKYL RNFINGGPPG YAPYCEERLR RTFANGTRTQ PPSWLELQAT KSKKPIMLPV
TFMDGTTKTL LTDSATTAKE LCNSLADKIS LKDRFGFSLY IALFDKVSSL GSGNDHVMDA
VSQCEQYAKE QGAQERNAPW RLFFRKEIFT PWHNPSEDNV ATNLIYQQIV RGVKFGEYRC
DKEEDLAELA SQQYYVDYGS EMVLERLLNL IPSYIPDREI TTSKTVEKWA QLIIAAHKKG
IYTQKRADPK KVKEEVVDFA RFKWPLLFSR FYEAFKFSGP SLPKNDVIVA VNWTGVYFVD
EQEQVLLELS FPEITAVSSS RGGKLQGQSF TLATIKGDEY TFTSNNAEDI RDLVVTFLEG
LRKRSKYVVT LQDNPNPVGE ESGFLSFLKG DLIVLDQDTG EHVMSSGWAN GFNERTKQRG
DFPTDSVYVL PTVTMPPLEI VALVTMTPDQ RQDVIRTSQL AISDSEERVK PYTLEEFSYD
YFRPPPKHTL SRVMITKSRG KDKLWCYTRE PIKQPLLKKI LGSEELSQEA CMAFIDILPL
PGGALGQQPI LDSCLPPVLK YMGDYPSKRT RSVNELTDQI FEGALKAEPL KDEVYCQTLK
QLTDNHIKYS EEKGWELLWL CTGLFPPSNI LLPHVQRFLQ SRKHHPLAAD CIQRLQKALR
NGSRKYPPHL VEVEAIQHKT TQIFHKVYFP DDTDEAFEVE SSTKAKDFCQ NISNRLLLKS
SEGFSLFVKI SDKVISVPEG DFFFDFVRHL TDWIKKARPA KDGIVPSLTY QVFFMKKLWT
NTTPGKDSMA DSIFHYYQEL PKYLRGYHKC TREEVLQLAA LIYRVKFEDD KSYFPSIPKL
LKEMVPQDLI RQLSPDDWKR SIVAYYNKHA GKTREEAKLA FLKIIFKWPT FGSAFFEVKQ
TTEPNYPEIL LIAINKHGVS LIDPKTKDIL ITHPFTKISN WSSGNTYFHI TIGNLVRGSK
LLCETSLVRS VKDYWAQLNQ ILTLAGK
//
