UniProt: A0A093NNM6

Database: UniProt
Entry: A0A093NNM6_PYGAD

LinkDB:  A0A093NNM6_PYGAD 
Original site:  A0A093NNM6_PYGAD

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Ontology (10)   
   GO (10)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (34)   
   InterPro (20)   
   Pfam (11)   
   PROSITE (2)   
   SMART (1)   
All databases (45)   

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ID   A0A093NNM6_PYGAD        Unreviewed;      3496 AA.
AC   A0A093NNM6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Dynein heavy chain 7, axonemal {ECO:0000313|EMBL:KFW61752.1};
DE   Flags: Fragment;
GN   ORFNames=AS28_03208 {ECO:0000313|EMBL:KFW61752.1};
OS   Pygoscelis adeliae (Adelie penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX   NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW61752.1, ECO:0000313|Proteomes:UP000054081};
RN   [1] {ECO:0000313|EMBL:KFW61752.1, ECO:0000313|Proteomes:UP000054081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW61752.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC       axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; KL224607; KFW61752.1; -; Genomic_DNA.
DR   STRING; 9238.A0A093NNM6; -.
DR   Proteomes; UP000054081; Unassembled WGS sequence.
DR   GO; GO:0005930; C:axoneme; IEA:UniProt.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46961:SF18; DYNEIN AXONEMAL HEAVY CHAIN 1; 1.
DR   PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..3496
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001885537"
FT   DOMAIN          1712..1747
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          2303..2351
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW61752.1"
FT   NON_TER         3496
FT                   /evidence="ECO:0000313|EMBL:KFW61752.1"
SQ   SEQUENCE   3496 AA;  400209 MW;  C9E933F6FE4A2F7E CRC64;
     KLFNVLTTVI FVLQYVRLGM FELHCDELIS ALVKRADNIC EKVISKMFKD HQDINARLCD
     EFERISEKAL TTPSNTQELM ELKACMQKVE TRDMLELRQK LVDALNCVAF LIECVNFSPA
     DIRLNSNVFQ WYARMPDIFE EHRRIIKEKT DQFQDGLKIR CEQFVEELKS YSKQVEELST
     FGDIQEVNRY LKKAQALNIK LDLAADKIDQ FNSEEESFGW PVSQYPQHKN IRNTLAPYLR
     LYDMTVEFNR RHKDWTEGSF TEVNPDKVEV DVGNYWHGLY KLEKAFHNSP NALAITRQVK
     SKVEEFRCHI PLIQVICNPG LQERHWEEMS KIAGLPLSPS EDSNVLSYIN LHLEPFLEKF
     ETISETASKE HSLEKALTKM ISEWDQMEFT LLAYRETGTH ILSSVDDIQM LLDDHIVKTQ
     TMRGSPFIKH YEKRIREWEG KLLLVQEILD EWLKVQATWL YLEPIFSSPD IMAQMPEESR
     QFSTVVKTWK DLMKSVFQDK HVLTVVIIDK MLEKLRKCNE FLELILKGLN EYLEKKRLFF
     PRFFFLSNDE LLEILSETKD PTRVQPHLKK CFEGIARVEF TDVLDITHIK SSEGETVELI
     ETISTSEARG QVEKWLVELE AAMLKSVHKV IGDALEAYLK TPRVNWVREW PGQTVLCVSQ
     TFWTMQVQMS IRNGQTALED FLEQNNRQIE DIVTLVRGKL SKQNRVTLGA LVVLDVHARD
     VLASLVSKKV KDESDFEWLS QLRYYWEEGH LQTKMINAGL RYGYEYLGNT PRLVITPLTD
     RCYRTLFGAL HLHLGGAPEG PAGTGKTETT KDLAKAVAKQ CVVFNCSDGL DYLALGKFFK
     GLLSCGAWAC FDEFNRIDLE VLSVVAQQIF TIQRGINSGS DLIVFEGTEL KLNPTCAVFI
     TMNPGYAGRS ELPDNLKALF RTVAMMVPDY AMIAEIVLYS CGFVTARPLS VKIVATYRLC
     SEQLSSQHHY DYGMRAVKSV LTAAGNLKLK YPLEDEEILL LRSITDVNLP KFLSHDLPLF
     EGITSDLFPG MKLPKPDYSD LLEAIKTNCD AMNLQMTDVF TMKILQIYEM MIVRHGFMIV
     GEPFGGKTCA YRVLAGALGD ICEKGLMEEN KVQITVLNPK SITMGQLYGQ FDPVSHEWSD
     GILAVSFRAF ASSPTPDRKW LVFDGPVDAV WIENMNTVLD DNKKLCLMSG EIIKMSQQMS
     LIFEPMDLEV ASPATVSRCG MVYMEPHMLG WRPLMMSWLN TMHSGISSMH KEFIIDLFDR
     MVPLCLEFIR KYTKELSPTS DTNLIQSLMN LMDCMMDEFA DEAKVKAMND HDILSWLEGI
     FLFSLIWSVG ASCKEDDRLK FDKVVREMLN GPISEETKEQ YKLLSSIDQQ PSKTFTVPFP
     TEGTIYDYRF VKKGAGIWEP WVETLKSAPP IPQDMMFNEI IVPTLDTVRY MALMELLTVH
     QKPSVFVGPT GTGKSTYITN FLLNNLNKDV YKPLRINFSA QTTAAQTQNI IMSKLDKRRR
     GIFGPPLGKR MVVFVDDVNM PAREVYGAQP PVELLRQWLD HWNWYDLKDC SVIKLVDVQI
     VCAMGPPGGG RNPVTSRFLR HFNTVTINEF DDESMYTIFS RILDWHLTVC YSFPSQYVEL
     TPQIINGTMR MYKEARKNLL PTPAKSHYLF NLRDFSRVIQ GVCLSRPETT ESAGMIKRLW
     VHEVLRVYYD RLVDNPDRAW LVGFIQEVVK NYLHEDFDEL FQNLDFNNDG RVEEDDLRSL
     MFCDFHDPKR EDTKYREISD VDQLRLVVES HLEEFNNMSK KPMQLVLFRF AIEHICRISR
     ILKQPRSHAL LVGVGGSGRQ SLTRLAAHMA EYNLFQVEIT KSYGINEWHK DLKVILRQST
     EGEMQGVFLF TDTQIKKESF LEDINNLLNA GEVPNLFAVD EKQEICEKMR QVDRQWDRTK
     QTDGSPIALF NKFVDRCRDR LHIVLAMSPI GDAFRNRLRK FPALVSCCTL DWFQTWPEDA
     LEAVASRFLE DVEMSKETRS GCIDMCKSFH TSTIVLSDLY HAELQRHNYV TPTSYLELIS
     TFKSLLEKKR IKVMKMKRRY EVGLEKLNSA ASEVALMQSE LEALQPQLRE ASKQVDEMMV
     VIQKESLEVA KTEKVVKADE AVANEQAMAA KAIKDECDAD LAQAMPCLES ALAALDTLTA
     QDITVVKSMK SPPAGVKLVM EAICILKGIK ADRIPDPTGS GKKIEDFWGP AKRLLGDIRF
     LQSLHEYDKD NIPPAYMAII RKQYLTNPEF VPDKIRNAST AAEGLCKWVI AMEFYDTVTK
     NVAPKKLKLN QAEGKLKIAM DGLRKKQADL RDVQDKLAVL QQTLESKKQE KADLENQVDL
     CSKKLQRAEQ LIGGLGGEKT RWHETALELG RQYINLTGDI LISSGIVAYL GAFTSSYRQM
     QTKEWALLCK TKDIPCSDDF SLTNTLGEPV EIRAWNIAGL PTDMFSIDNG IIISNARRWP
     LMIDPQGQAN KWIKNMEKAN SLHIIKLSDP QFITTLENCI QFGSPVLLEN VGEELDPILE
     PLLLKQTFKQ SGSICICLGD STIEYAPEFR FYITTKLRNP HYLPETSVKV TLLNFMITSE
     GMQDQLLGIV VARERPDLEE EKQALILQGA ENKRQLKEIE DKILEVLSAS EGNILEDETA
     IKILSSSKVL ANEISEKQAV AEETEKKIDA TRMGYRPIAI HSSILFFSIA DLANIDPMYQ
     YSLMWFINLF IMSVDNSEQS EVLQTRLKIL KDHFTYSLYV NVCRSLFEKD KLLFSFCLTA
     NLLKYEKLIN ENEWKFLLTG GIGLDNPFSN PCTWLPPKSW DEICRLEDLP CFTNIRKDFT
     RLKDGWKLVY DSSDPQHEDF PAEWQKKLGE FQRMLIIRCL RPDKIIPMVQ EFIIHNLGRP
     FIEPPPFDLS KAFSDSHSCA PLIFILSPGA DPMAALLKFA DDQGFGGTKL SSLSLGQGQG
     PIAMKMIEKA VKEGTWIVLQ NCHLASSWMP ILEKVCEELN PDTTHPDFRI WLTSYPSATF
     PVSVLQNGVK MTNEAPKGLR ANIIRSYLMD PISDSDFFNS CRKPVSNFKT LLYGLCFFHA
     LVQERRNFGP LGWNIPYEFN ETDLRISVQQ LRIFLDQYEE VPYDALRYMT GECNYGGRVT
     DDWDRRTLRS VLNMFFSSEI ITNVDYKFDA SGLYFAPPEG DYQSYIEYTK TLPLNPSPEI
     FGMNANADIT KDQSETQLLF DNILLTQSRA SGGGGKSTDE VVHEVTGDIL SKLPPNFDIE
     ATMRRYPTTY TQSMNTVLVQ EMGRFNKLLQ TIRDSCVNIQ KAIKGLVVMS AELEEVVNSI
     LKGKIPGLWM SKSYPSLKPL GSYVTDFLNR LKFLQLWYEN GTPPVFWISG FFFTQAFLTG
     AQQNYARKYT IPIDLLEFDY EVLEDKEYEI APEDGVYVQG LFLDGARWNR QTKKLGESHP
     KILYDTVPVI WLKPCKRADI PQRPSYLAPV YKTSERRGIL STTGHSTNFV IAMTLPSDKP
     QEHWIRRGVA LLCQLN
//

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