ID A0A093NRK6_PYGAD Unreviewed; 705 AA.
AC A0A093NRK6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=DNA excision repair protein ERCC-3 {ECO:0000256|ARBA:ARBA00032205};
DE Flags: Fragment;
GN ORFNames=AS28_13183 {ECO:0000313|EMBL:KFW66751.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW66751.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW66751.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW66751.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; KL225037; KFW66751.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093NRK6; -.
DR STRING; 9238.A0A093NRK6; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:KFW66751.1};
KW Helicase {ECO:0000313|EMBL:KFW66751.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000313|EMBL:KFW66751.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054081}.
FT DOMAIN 249..410
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 464..624
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 142..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW66751.1"
FT NON_TER 705
FT /evidence="ECO:0000313|EMBL:KFW66751.1"
SQ SEQUENCE 705 AA; 80260 MW; 8389F546EC58BE2D CRC64;
APDGHIFLEA FSPVYKYAQD FLVAIAEPVC RPTHIHEYKL TAYSLYAAVS VGLQTSDITE
YLQKLSKTGV PDGIIQFIKL CTVSYGKVKL VLKHNRYFVE STHPDVIQQL LQDHVIRDCR
LRNAEGEETE LITETFTSKS AISKSSEGGF GPSTSQGTDA QNKPDVPADL FEFYEQMDKD
EEEEEETQTV SFEVKQEMIE ELQKRCIHLE YPLLAEYDFR NDSVNPDINI DLKPTAVLRP
YQEKSLRKMF GNGRARSGVI VLPCGAGKSL VGVTAACTVR KRCLVLGNSA VSVEQWKAQF
KMWSTIDDSQ ICRFTSDAKD KPIGCSIAIS TYSMLGHTTK RSWEAERVME WLKSQEWGLM
ILDEVHTIPA KMFRRVLTIV QAHCKLGLTA TLVREDDKIV DLNFLIGPKL YEANWMELQN
SGYIAKVQCA EVWCPMSPEF YREYVAIKTK KRILLYTMNP NKFRACQFLI KFHERRNDKI
IVFADNVFAL KEYAIRLGKP FIYGPTAQGE RMQILQNFKH NPKINTIFIS KVGDTSFDLP
EANVLIQISS HGGSRRQEAQ RLGRVLRAKK GMVAEEYNAF FYSLVSQDTQ EMAYSTKRQR
FLVDQGYSFK VITKLAGMEE EELSFSSKEE QQQLLQKVLQ ASDLDAEEEV VAGEYGSKSA
QVSRRTGTMS SMSGADDAVY MEYHSSRSKA SSNKHIHPLF KRFRK
//
