ID   A0A093NSW4_PYGAD        Unreviewed;       560 AA.
AC   A0A093NSW4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Amiloride-sensitive sodium channel subunit alpha {ECO:0000313|EMBL:KFW67893.1};
DE   Flags: Fragment;
GN   ORFNames=AS28_08681 {ECO:0000313|EMBL:KFW67893.1};
OS   Pygoscelis adeliae (Adelie penguin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX   NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW67893.1, ECO:0000313|Proteomes:UP000054081};
RN   [1] {ECO:0000313|EMBL:KFW67893.1, ECO:0000313|Proteomes:UP000054081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW67893.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KL225141; KFW67893.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A093NSW4; -.
DR   STRING; 9238.A0A093NSW4; -.
DR   Proteomes; UP000054081; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF132; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT DELTA; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000313|EMBL:KFW67893.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        49..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFW67893.1"
FT   NON_TER         560
FT                   /evidence="ECO:0000313|EMBL:KFW67893.1"
SQ   SEQUENCE   560 AA;  64544 MW;  A0FEFF2F0C5C671A CRC64;
     EEEKKEGLIE FYDSFRDMFE FFCKNTTIHG TIRLVCSDSN RMKTAFWTLL LLASFGMLYW
     QFALMFSQYW AYPVVLTMSM HSEPKMFPAI TICNLDPYRF ELVSEHLVQL DHMAEESIAF
     LYGINTSASL FHVNEKNIHV KDLSSIGNLS RSSFKLSQNF SLLRMPDHNN RSGKKHSNVG
     FRLCNATGGN CFYKTYSSGM DAILEWYRFH YMNIMSQLPV IVNISDHEEQ IEDMVYSCQY
     DGEPCRPSDY VHFHHPVFGS CYTFNSKGTD PFWTATKPGI PYGLSLILRA EQKDHIPLLS
     TVAGVKVMIH NHNQTPFLEH EGFDIRPGIA TIIGIQQDEV NRLGGNYGKC TTNGNDVNVK
     LLYNNSYTLQ ACLHSCFQHI MVRKCGCGYY YYPLPPGAEY CNYNKQPAWG HCFYQLYNRL
     RNHHLNCFDQ CPKPCRESLY KVSAGTAKWP SAKSQDWIRQ ALRHQNGYNS TSNRKDIAKV
     TIFYQQLNYE SVNESPLLSE NLLLSSMGSQ WSLWFGSSVL SVVEMFELLI DTLVLSLLFC
     YQRFRSKKTL KVARTPTIPS
//