ID A0A093P472_PYGAD Unreviewed; 369 AA.
AC A0A093P472;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 35.
DE SubName: Full=Bone morphogenetic protein 7 {ECO:0000313|EMBL:KFW69045.1};
DE Flags: Fragment;
GN ORFNames=AS28_06977 {ECO:0000313|EMBL:KFW69045.1};
OS Pygoscelis adeliae (Adelie penguin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Sphenisciformes; Spheniscidae; Pygoscelis.
OX NCBI_TaxID=9238 {ECO:0000313|EMBL:KFW69045.1, ECO:0000313|Proteomes:UP000054081};
RN [1] {ECO:0000313|EMBL:KFW69045.1, ECO:0000313|Proteomes:UP000054081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_AS28 {ECO:0000313|EMBL:KFW69045.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KL225217; KFW69045.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093P472; -.
DR STRING; 9238.A0A093P472; -.
DR Proteomes; UP000054081; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19397; TGF_beta_BMP7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF135; BONE MORPHOGENETIC PROTEIN 7; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000054081};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 250..369
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 229..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW69045.1"
FT NON_TER 369
FT /evidence="ECO:0000313|EMBL:KFW69045.1"
SQ SEQUENCE 369 AA; 41937 MW; 54F45DACB7B42E00 CRC64;
RPRPHLHGKH NSAPMFMLDL YNAMSVEEGA AGAAAEEGEG FSYPYKPIFS TQGPPLASLQ
DSNFLTEADM VMSFVNLVEH DREFHHQRCH YREFRFDLSR IPEGEAVTAA EFRIYKDYIR
ERFDNETFQI SVYQVLQEHP GRDSDLFLLD SRTIWAAEEG WLVFDITATS NHWVVNPQHN
LGLQLSVEGI DGQSINPKLA GLIGRHGPQN KQPFTVAFFK ATEVHLRSIR STGGKQRSQN
RSKTPKNQEA FRVSNIAENS SSDQRQACKK HELYVSFRDL GWQDWIIAPE GYAAYYCEGE
CAFPLNSYMN ATNHAIVQTL VHFINPETVP KPCCAPTQLN AISVLYFDDS SNVILKKYRN
MVVRACGCH
//
