ID A0A093PHY8_9PASS Unreviewed; 766 AA.
AC A0A093PHY8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Ribosomal protein S6 kinase alpha-5 {ECO:0000313|EMBL:KFW76031.1};
DE Flags: Fragment;
GN ORFNames=N305_01322 {ECO:0000313|EMBL:KFW76031.1};
OS Manacus vitellinus (golden-collared manakin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Pipridae; Manacus.
OX NCBI_TaxID=328815 {ECO:0000313|EMBL:KFW76031.1, ECO:0000313|Proteomes:UP000053258};
RN [1] {ECO:0000313|EMBL:KFW76031.1, ECO:0000313|Proteomes:UP000053258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N305 {ECO:0000313|EMBL:KFW76031.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. S6 kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00009804}.
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DR EMBL; KL669381; KFW76031.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093PHY8; -.
DR STRING; 328815.ENSMVIP00005006716; -.
DR Proteomes; UP000053258; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14179; STKc_MSK1_C; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016239; Ribosomal_S6_kinase_II.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR PANTHER; PTHR24351:SF115; RIBOSOMAL PROTEIN S6 KINASE ALPHA-5; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00433; Pkinase_C; 1.
DR PIRSF; PIRSF000606; Ribsml_S6_kin_2; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000606-
KW 51}; Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFW76031.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000606-51};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053258};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 16..285
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 286..354
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT DOMAIN 393..654
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 708..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 144
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
FT ACT_SITE 511
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-50"
FT BINDING 399..407
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51"
FT BINDING 422
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000606-51,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFW76031.1"
FT NON_TER 766
FT /evidence="ECO:0000313|EMBL:KFW76031.1"
SQ SEQUENCE 766 AA; 86600 MW; 4D9FA7825B5F3FBD CRC64;
SANLTGHAEK VGIENFELLK VLGTGEWLGL EGSTGGHLVQ SLLKQINLGH VAQDCMQVGF
EYLQRWRLHN LSGQPLPLCC HPQSKEDLPH IHVEFHIFNY INGGELFTHL SHRERFSESE
VQIYIGEIVL ALEHLHKLGI IYRDIKLENI LLDSDGHVVL TDFGLSKEFL TDENERAYSF
CGTIEYMAPD IVRGGDTGHD KAVDWWSVGV LMYELLTGAS PFTVDGEKNS QAEISRRILK
SEPPYPQEMS ALSKDIIQRL LMKDPKKRLG CGPTDADEIK QHPFFQNMNW DDLAAKKIPA
PFKPVIRDEL DVSNFAEEFT EMDPTYSPAA TPQTSERIFQ GYSFVAPSIL FKRNAATVDP
LQFYMGDERP GTTTIARSAM MKDSPFYHHY ELDLKEKPLG EGSFSICRKC LHKKTSQEYA
VKIISKRMEA NTQREITALK LCEGHPNVVK LHEVFHDQLH TFLVMELLKG GELLERIQKK
KHFSETEASH IMRRLVSAVS HMHDVGVVHR DLKPENLLFT DETDNSEIKI IDFGFARLKP
PDNQPLKTPC FTLHYAAPEL LNHNGYDESC DLWSLGVILY TMLSGQVPFQ SQDRSLTCTS
ALEIMKKIKK GEFSFEGEAW KNVSEEAKEL IRGLLTVDPN KRIKMSSLRY NEWLQDGSQL
SSNPLMTPDN LGSSGAAVHT YVKATFHAFN KYKREGFCLQ NVDKAPLAKR RKMKKTSTST
ETRSSSSESS HSSSSHSHGK TTPTKTLQPT NPADSNNPET IFQFSD
//
